Nadya Morozova

Research interests :

Current Research Fields:

• Geometry of Morphogenesis
• Mathematical modeling of the processes of growth and development
• Cell fate determination in the process of development
• Pathway and Network analysis
• Cancer biology, with a focus on cancer stem cells populations

Current Research projects:

• Mathematical formalization of pattern formation in morphogenesis
• Mathematical modeling of cancer stem cells population dynamics (with Dr. C. Ginestier, CNRS, Marseille)
• Mathematical modeling of the processes of growth and development in zebrafish embryos

Scientific Collaborations :

Previous Research Fields / projects :

Interdisciplinary:

Pathway and Network analysis

• Network modeling of proliferation/cancer/apoptotic pathways in human lung cancer cells using a genome-wide loss of function screen
• Systems biology approach for genome-wide loss-of-function screen analysis, with applications to lung cancer research
• Network and pathway analysis on the set of data of mammalian muscle cell differentiation

Mathematical modeling

• Mathematical modeling of different mechanisms of microRNA action (with Dr. Zinovyev, Institut Curie and Dr. A. Harel-Bellan, CNRS FRE 3377)
• Mathematical Modelling of Cancer Stem Cells Population Behavior (with Prof. V. Capasso, University of Milano, Italy)
• Mathematical modeling of plant growth (with Dr. V. Volpert, Lyon, France)

Bioinformatics

• Bioinformatic analysis of the deep sequencing of small non-coding RNAs, associated with chromatin AGO-complexes (with Dr. A. Harel-Bellan, CNRS FRE 3377)
• Bioinformatic analysis of microRNA profiling data done by LNA microarray and TLDA qPCR technique, for the processes of proliferation, differentiation and cancerogenesis
• Developing the data processing software for new high throughput microarray technology (with Prof. Khrapko, Harvard Medical School, USA)
• Biostatistics for genome-wide screen analysis
• Bioinformatic analysis of genome-wide data on miRNA function in mammalian muscle cell differentiation

In Biology:

Cell differentiation and pattern formation

• morphophysiological correlations in plant embryogenesis
• regulation of cell cycle progression during plant cell differentiation and dedifferentiation
• regulatory effect of CLAUSA gene on homeobox gene LeT6/TKn2, regulating pattern formation in tomato plants embryos
• the role of two novel selenoproteins in the Drosophila embryo pattern formation

Signal transduction

• TRAPP complex as a dual-Ypt/Rab GEF required for protein traffic

Regulation of protein translation

• special machinery of selenoprotein translational mechanism

Oxidative stress

• oxidative stress in human neuronal cells

In Physics:

Classical field theory

• theory of the temporal-angular distribution of the radiation of the groups of relativistic charged particles

Publications :

Papers:

• D. Touroutine and N. Morozova. A novel hypothesis about mechanism of thalidomide action on pattern formation. Biosystems. 2024 Dec;246:105344.
• A. Minarsky, S. Krymsky, C. Soulé and N. Morozova. Model of morphogenesis with repelling signaling. Acta Biotheoretica. 2022 Dec 20;71(1):4.
• O. Butuzova, A. Minarsky, C. Soulé and N. Morozova. Determinism and Variability of Morphogenesis Pathways. Dev Biol. 2021 Nov;479:1-10.
• O. Butuzova, N. Pakudin, A. Minarsky, N. Bessonov, N. Morozova. Developmental graphs comparison strategy for analysis of pattern formation and phylogeny. J Theor Biol. 2021 Oct 12:110925.021.
• Y. Wang, B. Zhang, J. Kropp, N. Morozova. Inference on tissue transplantation experiments. J Theor Biol. 2021 Jul 7;520:110645.
• Y. Wang, A. Minarsky, R. Penner, C. Soulé, N. Morozova. Model of Morphogenesis. J Comput Biol. 2020;27(9):1373-1383.
• Y. Wang, J. Kropp, N. Morozova. Biological notion of geometrical positional values in morphogenesis theory. Int. Journal of Developmental Biology. 2020;64(10-11-12):453-463.
• N. Rubanova, G. Pinna, J. Kropp, A. Campalans, J. P. Radice, A. Polesskaya, A. Harel-Bellan, N. Morozova. MasterPATH: network analysis of functional genomics screening. BMC Genomics. 2020 Sep 14;21(1):632.
• N. Bessonov, G. Pinna, A. Minarsky, A. Harel-Bellan, N. Morozova. Mathematical modeling reveals the factors involved in the phenomena of cancer stem cells stabilization. PLoS One. 2019 Nov 11;14(11):e0224787.
• N. Bessonov, O. Butuzova, A. Minarsky, C. Soulé, R. Penner, A. Tosenberger, N. Morozova. Morphogenesis Software based on Epigenetic Code Concept. Computational and Structural Biotechnology Journal. 2019;17:1203-1216.
• N. Rubanova and N. Morozova. Centrality and the shortest path approach in the human interactome. Journal of Bioinformatics and Computational Biology. 2019;17(04):1950027.
• A. N. Gorban, A. Harel-Bellan, N. Morozova, A. Zinovyev. Basic, simple and extendable kinetic model of protein synthesis. Mathematical Biosciences and Engineering. 2019;16(6):6602-6622.
• A. Minarsky, N. Morozova, R. Penner, C. Soulé. Theory of Morphogenesis. Journal of Computational Biology. 2018;25:1-7.
• C. A. Azencott, T. Aittokallio, S. Roy, DREAM Consortium (N. Morozova), T. Norman, S. Friend, G. Stolovitzky, A. Goldenberg. The inconvenience of data of convenience: computational research beyond post-mortem analyses. Nature Methods. 2017;14:937-938.
• N. Bessonov, M. Levin, N. Morozova, N. Reinberg, A. Tosenberger, V. Volpert. Target morphology and cell memory: a model of regenerative pattern formation. Neural Regeneration Research. 2015;10(12):1901-1905.
• A. Polesskaya, G. Pinna, Y. Sassi, N. Morozova, A. Harel-Bellan, C. Degerny. Post-transcriptional modulation of Interleukin-8 by CNOT6L regulates skeletal muscle differentiation. Biochim Biophys Acta. 2015 Dec 1;1863(2):263-270.
• A. Tosenberger, N. Bessonov, M. Levin, N. Reinberg, V. Volpert, N. Morozova. A conceptual model of morphogenesis and regeneration. Acta Biotheoretica. 2015;63(3):283-294.
• N. Morozova, R. Penner. Geometry of Morphogenesis. In: BIOMAT 2014, World Scientific Proceedings, 2015.
• N. Bessonov, M. Levin, N. Morozova, N. Reinberg, A. Tosenberger, V. Volpert. Model of Pattern Regeneration Based on a Cell Memory. PLoS One. 2015 Feb 19;10(2):e0118091.
• J. Kropp, C. Degerny, N. Morozova, J. Pontis, A. Harel-Bellan, A. Polesskaya. MiR-98 delays skeletal muscle differentiation by downregulating E2F5. Biochem J. 2015 Feb 15;466(1):85-93.
• A. Polesskaya, C. Degerny, G. Pinna, Y. Maury, G. Kratassiouk, V. Mouly, N. Morozova, J. Kropp, N. Frandsen, A. Harel-Bellan. Genome-wide exploration of miRNA function in mammalian muscle cell differentiation. PLoS One. 2013 Aug 21;8(8):e71927.
• A. Zinovyev, N. Morozova, A. N. Gorban, A. Harel-Bellan. Mathematical Modeling of microRNA-Mediated Mechanisms of Translation Repression. Adv Exp Med Biol. 2013;774:189-224.
• N. Morozova, M. Shubin. The Geometry of Morphogenesis and the Morphogenetic Field Concept. Springer Proceedings in Mathematics. 2012;15:255-282.
• N. Mercatelli, C. Beldiman, M. L. Nairismagi, G. Kratassiouk, L. A. Largitte, N. Morozova, L. L. Pritchard, R. Groisman, A. Harel-Bellan. Elevated miR205 expression and breast epithelial cell transformation. OncoMiRs. 2012;1:2–9. doi:10.2478/oncor-2012-0002.
• M. Ameyar-Zazoua, C. Rachez, M. Souidi, P. Robin, L. Fritsch, N. Morozova, R. Young, J. Mathieu, A. Hamiche, S. Ait-Si-Ali, C. Muchardt, E. Batsché, A. Harel-Bellan. Coupling of chromatin silencing to alternative splicing by human nuclear Argonaute proteins. Nature Struct Mol Biol. 2012;19(10):998-1004.
• L. Galluzzi, … Morozova N, … Kroemer G. Prognostic Impact of Vitamin B6 Metabolism in Lung Cancer. Cell Rep. 2012;2(2):257-269.
• N. Morozova, A. Zinovyev, N. Nonne, L. L. Pritchard, A. N. Gorban, A. Harel-Bellan. Kinetic signatures of microRNA modes of action. RNA. 2012;18(9):1635-1655.
• G. Pinna, A. Zinovyev, N. Araujo, N. Morozova, A. Harel-Bellan. Analysis of the Growth Control Network Specific for Human Lung Adenocarcinoma Cells. Math Mod Nat Phen. 2012;7(01):337–368.
• E. Beretta, V. Capasso, N. Morozova. Mathematical Modelling of Cancer Stem Cells Population Behavior. Math Mod Nat Phen. 2012;7(01):279–305.
• V. Brukhin, N. Morozova. Plant Growth and Development - Basic Knowledge and Current Views. Math Mod Nat Phen. 2011;6:1-53.
• A. Zinovyev, N. Morozova, N. Nonne, E. Barillot, A. Harel-Bellan, A. N. Gorban. Dynamical modeling of microRNA action on the protein translation process. BMC Syst Biol. 2010;4:13.
• N. Bessonov, N. Morozova, V. Volpert. Modeling of branching patterns in plants. Bull Math Biol. 2008;70(3):868-893.
• Y. Liang, N. Morozova, A. A. Tokarev, J. W. Mulholland, N. Segev. The role of Trs65 in the Ypt/Rab guanine nucleotide exchange factor function of the TRAPP II complex. Mol Biol Cell. 2007;18(7):2533-2441.
• N. Morozova, Y. Liang, A. Tokarev, V. Scorria, S. Emr, N. Segev. Trs130 is required for the specificity switch of a dual-Ypt/Rab GEF. Nat Cell Biol. 2006;8(11):1263-1269.
• N. Morozova, K. Khrapko, J. Panee, W. Liu, J. W. Harney, M. J. Berry. Glutathione depletion in hippocampal cells increases levels of H and L ferritin and glutathione S-transferase mRNAs. Genes Cells. 2007;12(5):561-577.
• A. Small-Howard, N. Morozova, Z. Stoytcheva, E. P. Forry, J. B. Mansell, J. W. Harney, B. A. Carlson, X.-M. Xu, D. L. Hatfield, M. J. Berry. Supramolecular complexes mediate selenocysteine incorporation in vivo. Mol Cell Biol. 2006;26(6):2337-2446.
• L. A. de Jesus, P. R. Hoffmann, T. Michaud, E. P. Forry, A. Small-Howard, R. J. Stillwell, N. Morozova, J. W. Harney, M. J. Berry. Nuclear assembly of UGA decoding complexes on selenoprotein mRNAs: a mechanism for eluding nonsense-mediated decay? Mol Cell Biol. 2006;26(5):1795-1805.
• N. Morozova, E. Bragina, V. Vasiljeva. Dynamics and role of glycoconjugates of plant cell wall in embryoidogenesis. Phytomorphology. 2006;56(3&4):1-7.
• N. Morozova, E. P. Forry, E. Shahid, A. M. Zavacki, J. W. Harney, Y. Kraytsberg, M. J. Berry. Antioxidant function of a novel selenoprotein in Drosophila melanogaster. Genes Cells. 2003;8(12):963-971.
• L. Williams, J. Zhao, N. Morozova, Y. Li, Y. Avivi, G. Grafi. Chromatin Reorganization Accompanying Cellular Dedifferentiation... Dev Dyn. 2003;228(1):113-120.
• M. J. Berry, G. W. Martin III, R. Tujebajeva, E. Grundner-Culemann, J. B. Mansell, N. Morozova, J. Harney. Selenocysteine insertion sequence element characterization and selenoprotein expression. Methods Enzymol. 2002;347:17-24.
• S. Castellano, N. Morozova, M. Morey, M. Berry, F. Serras, M. Corominas, R. Guigo. In Silico identification of novel selenoproteins in the Drosophila melanogaster genome. EMBO Rep. 2001;2(8):697-702.
• J. Zhao, N. Morozova, L. Williams, L. Libs, Y. Avivi, G. Grafi. Two Phases of Chromatin Decondensation during Dedifferentiation... J Biol Chem. 2001;276(25):22772-22778.
• Y. Avivi, S. Lev-Yadun, N. Morozova, L. Libs, L. Williams, J. Zhao, G. Varghese, G. Grafi. Clausa, a tomato mutant... Plant Physiol. 2000;124(2):541-552.
• N. P. Klepikov, N. M. Morozova. Dependence of intensity of synchrotron radiation... Vestnik of Moscow University. 1996;37:13-17. (In Russian).
• N. M. Morozova, V. E. Vasiljeva. The phenomena of long life capability of the fruitlets of Nelumbo nucifera G. Bot. J. 1993;78(8):47-50. (In Russian).
• N. M. Morozova, I. P. Ermakov. Analysis of the genes expressed during plant embryogenesis. Science and technique news, biotechnology. 1991;11:1-39. (In Russian).

Jump to Books · Jump to Chapters

Books :

Book Editing:

• Pattern Formation in Morphogenesis - Problems and Mathematical Issues. Editors: V. Capasso, M. Gromov, A. Harel-Bellan, N. Morozova (Editor-in-Chief), L. L. Pritchard. Springer Proceedings in Mathematics, v 15, 2012.

Chapters in books :

• Zinovyev A, Morozova N, Gorban AN, Harel-Belan A. Mathematical Modeling of microRNA-Mediated Mechanisms of Translation Repression. In: MicroRNA Cancer Regulation. Advanced Concepts, Bioinformatics and Systems Biology Tools. Ed. by: U. Schmitz, O. Wolkenhauer, J. Vera, 2013.
• Beretta E, Capasso V, Harel-Bellan A, Morozova N. Some Results on the Population Behavior of Cancer Stem Cells. In: New Challenges for Cancer Systems Biomedicine. d’Onofrio, Cerrai, Gandolfi (eds), Simai Springer Series, 2012.
• Morozova N, Shubin M. The Geometry of Morphogenesis and the Morphogenetic Field Concept. In: Pattern Formation in Morphogenesis - Problems and Mathematical Issues. Springer Proceedings in Mathematics, v 15, pp. 255-282, 2012.
• Morozova N. M. Gene expression during plant embryogenesis. In: Embryology of flowering plants v.2 “Seed” (Ed. Batygina, T. B.), 1997, pp. 606-616, Mir & Semya Publishing Group, S-Petersburg. (In Russian).
• Vasiljeva V. E., Kolesova G. E., Morozova N. M., Ermakov I. P., Chochia K. A. Time and space concordance of the growth, differentiation and reproduction in higher plants. In: Sexual reproduction in higher plants. Ed. M. Cresti, P. Gori, E. Pacini, Springer-Verlag, 1988.

International Meetings Organization :

Scientific International Projects (on-going and finalized) :