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1: GO: Molecular Function [Display Chart] 150 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0044212 transcription regulatory region DNA binding 1.271E-14 7.077E-13 3.957E-12 1.906E-12 16 862
2 GO:0000975 regulatory region DNA binding 1.341E-14 7.077E-13 3.957E-12 2.012E-12 16 865
3 GO:0001067 regulatory region nucleic acid binding 1.415E-14 7.077E-13 3.957E-12 2.123E-12 16 868
4 GO:0003690 double-stranded DNA binding 1.608E-13 6.029E-12 3.371E-11 2.412E-11 15 824
5 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding 2.557E-13 7.672E-12 4.289E-11 3.836E-11 14 678
6 GO:0000976 transcription regulatory region sequence-specific DNA binding 4.350E-13 1.087E-11 6.080E-11 6.524E-11 14 705
7 GO:1990837 sequence-specific double-stranded DNA binding 7.800E-13 1.672E-11 9.346E-11 1.170E-10 14 736
8 GO:0008134 transcription factor binding 9.538E-13 1.788E-11 9.999E-11 1.431E-10 13 585
9 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding 9.616E-11 1.603E-9 8.961E-9 1.442E-8 10 365
10 GO:0001047 core promoter binding 1.081E-10 1.621E-9 9.063E-9 1.621E-8 8 165
11 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding 1.121E-9 1.529E-8 8.549E-8 1.682E-7 11 632
12 GO:0001012 RNA polymerase II regulatory region DNA binding 1.238E-9 1.548E-8 8.656E-8 1.858E-7 11 638
13 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding 3.559E-9 4.107E-8 2.296E-7 5.339E-7 9 380
14 GO:0000987 core promoter proximal region sequence-specific DNA binding 5.445E-9 5.687E-8 3.180E-7 8.168E-7 9 399
15 GO:0001159 core promoter proximal region DNA binding 5.687E-9 5.687E-8 3.180E-7 8.531E-7 9 401
16 GO:0001046 core promoter sequence-specific DNA binding 1.934E-8 1.813E-7 1.014E-6 2.901E-6 6 115
17 GO:0003682 chromatin binding 7.817E-7 6.898E-6 3.857E-5 1.173E-4 8 516
18 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding 2.336E-6 1.946E-5 1.088E-4 3.503E-4 6 259
19 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding 1.491E-5 1.177E-4 6.582E-4 2.237E-3 6 358
20 GO:0001102 RNA polymerase II activating transcription factor binding 2.677E-5 2.007E-4 1.122E-3 4.015E-3 3 38
21 GO:0033613 activating transcription factor binding 1.115E-4 7.964E-4 4.453E-3 1.673E-2 3 61
22 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1.410E-4 9.616E-4 5.377E-3 2.116E-2 3 66
23 GO:0003712 transcription cofactor activity 1.897E-4 1.237E-3 6.919E-3 2.846E-2 6 566
24 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific 2.063E-4 1.289E-3 7.208E-3 3.094E-2 2 14
25 GO:0000989 transcription factor activity, transcription factor binding 2.893E-4 1.729E-3 9.666E-3 4.340E-2 6 612
26 GO:0000988 transcription factor activity, protein binding 2.996E-4 1.729E-3 9.666E-3 4.495E-2 6 616
27 GO:0001158 enhancer sequence-specific DNA binding 3.889E-4 2.084E-3 1.165E-2
5.834E-2
 3 93
28 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding 3.889E-4 2.084E-3 1.165E-2
5.834E-2
 3 93
29 GO:0003714 transcription corepressor activity 4.476E-4 2.315E-3 1.294E-2
6.713E-2
 4 236
30 GO:0071837 HMG box domain binding 5.686E-4 2.761E-3 1.543E-2
8.529E-2
 2 23
31 GO:0035326 enhancer binding 5.705E-4 2.761E-3 1.543E-2
8.558E-2
 3 106
32 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding 7.052E-4 3.288E-3 1.838E-2
1.058E-1
 3 114
33 GO:0042826 histone deacetylase binding 7.234E-4 3.288E-3 1.838E-2
1.085E-1
 3 115
34 GO:0001085 RNA polymerase II transcription factor binding 7.796E-4 3.439E-3 1.923E-2
1.169E-1
 3 118
35 GO:0001221 transcription cofactor binding 9.711E-4 4.046E-3 2.262E-2
1.457E-1
 2 30
36 GO:0035035 histone acetyltransferase binding 9.711E-4 4.046E-3 2.262E-2
1.457E-1
 2 30
37 GO:0003713 transcription coactivator activity 1.254E-3 5.084E-3 2.842E-2
1.881E-1
 4 311
38 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding 1.331E-3 5.254E-3 2.938E-2
1.997E-1
 3 142
39 GO:0046982 protein heterodimerization activity 1.692E-3 6.507E-3 3.638E-2
2.538E-1
 5 575
40 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding 2.702E-3 1.013E-2
5.665E-2
4.053E-1
 3 182
41 GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding 3.715E-3 1.327E-2
7.419E-2
5.573E-1
 2 59
42 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding 3.715E-3 1.327E-2
7.419E-2
5.573E-1
 2 59
43 GO:0070491 repressing transcription factor binding 3.840E-3 1.339E-2
7.489E-2
5.760E-1
 2 60
44 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding 5.335E-3 1.819E-2
1.017E-1
8.002E-1
 2 71
45 GO:0036033 mediator complex binding 6.150E-3 2.037E-2
1.139E-1
9.225E-1
 1 4
46 GO:0046332 SMAD binding 6.246E-3 2.037E-2
1.139E-1
9.369E-1
 2 77
47 GO:0051525 NFAT protein binding 7.682E-3 2.452E-2
1.371E-1
1.000E0
 1 5
48 GO:0097322 7SK snRNA binding 9.212E-3 2.879E-2
1.609E-1
1.000E0
 1 6
49 GO:0001104 RNA polymerase II transcription cofactor activity 9.559E-3 2.926E-2
1.636E-1
1.000E0
 2 96
50 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding 1.176E-2 3.407E-2
1.905E-1
1.000E0
 2 107
Show 45 more annotations

2: GO: Biological Process [Display Chart] 1510 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000122 negative regulation of transcription from RNA polymerase II promoter 1.519E-8 2.294E-5 1.812E-4 2.294E-5 11 810
2 GO:0010243 response to organonitrogen compound 3.062E-8 2.312E-5 1.826E-4 4.623E-5 11 867
3 GO:0061614 pri-miRNA transcription from RNA polymerase II promoter 5.664E-8 2.851E-5 2.252E-4 8.553E-5 4 25
4 GO:1901698 response to nitrogen compound 1.093E-7 4.125E-5 3.258E-4 1.650E-4 11 982
5 GO:0072203 cell proliferation involved in metanephros development 5.413E-7 1.505E-4 1.189E-3 8.173E-4 3 11
6 GO:0008284 positive regulation of cell proliferation 6.930E-7 1.505E-4 1.189E-3 1.046E-3 10 927
7 GO:0051101 regulation of DNA binding 6.977E-7 1.505E-4 1.189E-3 1.054E-3 5 111
8 GO:0006352 DNA-templated transcription, initiation 1.277E-6 2.309E-4 1.823E-3 1.929E-3 6 233
9 GO:0009612 response to mechanical stimulus 1.376E-6 2.309E-4 1.823E-3 2.078E-3 6 236
10 GO:0009615 response to virus 3.166E-6 4.780E-4 3.775E-3 4.780E-3 7 430
11 GO:0030097 hemopoiesis 3.638E-6 4.925E-4 3.889E-3 5.493E-3 9 858
12 GO:0043620 regulation of DNA-templated transcription in response to stress 3.914E-6 4.925E-4 3.889E-3 5.909E-3 4 70
13 GO:0072111 cell proliferation involved in kidney development 4.995E-6 5.802E-4 4.582E-3 7.542E-3 3 22
14 GO:0048534 hematopoietic or lymphoid organ development 5.623E-6 5.875E-4 4.639E-3 8.491E-3 9 905
15 GO:1901652 response to peptide 6.348E-6 5.875E-4 4.639E-3 9.586E-3 7 478
16 GO:0072215 regulation of metanephros development 6.551E-6 5.875E-4 4.639E-3 9.892E-3 3 24
17 GO:0009314 response to radiation 6.614E-6 5.875E-4 4.639E-3 9.987E-3 7 481
18 GO:0048661 positive regulation of smooth muscle cell proliferation 7.735E-6 6.489E-4 5.125E-3 1.168E-2 4 83
19 GO:2000144 positive regulation of DNA-templated transcription, initiation 8.398E-6 6.624E-4 5.231E-3 1.268E-2 3 26
20 GO:0002520 immune system development 8.774E-6 6.624E-4 5.231E-3 1.325E-2 9 956
21 GO:0033002 muscle cell proliferation 9.301E-6 6.688E-4 5.282E-3 1.404E-2 5 188
22 GO:0045639 positive regulation of myeloid cell differentiation 1.021E-5 6.763E-4 5.341E-3 1.542E-2 4 89
23 GO:0007519 skeletal muscle tissue development 1.030E-5 6.763E-4 5.341E-3 1.555E-2 5 192
24 GO:0060538 skeletal muscle organ development 1.317E-5 8.017E-4 6.331E-3 1.989E-2 5 202
25 GO:0019086 late viral transcription 1.378E-5 8.017E-4 6.331E-3 2.081E-2 2 4
26 GO:0016032 viral process 1.380E-5 8.017E-4 6.331E-3 2.084E-2 8 759
27 GO:0045637 regulation of myeloid cell differentiation 1.448E-5 8.098E-4 6.396E-3 2.187E-2 5 206
28 GO:0044764 multi-organism cellular process 1.576E-5 8.500E-4 6.713E-3 2.380E-2 8 773
29 GO:2000142 regulation of DNA-templated transcription, initiation 1.749E-5 8.669E-4 6.846E-3 2.642E-2 3 33
30 GO:0048511 rhythmic process 1.761E-5 8.669E-4 6.846E-3 2.658E-2 6 368
31 GO:0031668 cellular response to extracellular stimulus 1.780E-5 8.669E-4 6.846E-3 2.687E-2 5 215
32 GO:0044419 interspecies interaction between organisms 2.171E-5 9.932E-4 7.844E-3 3.278E-2 8 808
33 GO:0044403 symbiosis, encompassing mutualism through parasitism 2.171E-5 9.932E-4 7.844E-3 3.278E-2 8 808
34 GO:0030099 myeloid cell differentiation 2.407E-5 1.069E-3 8.444E-3 3.635E-2 6 389
35 GO:0034097 response to cytokine 2.522E-5 1.088E-3 8.592E-3 3.808E-2 8 825
36 GO:0009991 response to extracellular stimulus 3.633E-5 1.524E-3 1.203E-2
5.485E-2
 7 626
37 GO:0048660 regulation of smooth muscle cell proliferation 4.548E-5 1.856E-3 1.466E-2
6.867E-2
 4 130
38 GO:0001568 blood vessel development 4.753E-5 1.889E-3 1.492E-2
7.177E-2
 7 653
39 GO:0032868 response to insulin 5.018E-5 1.933E-3 1.526E-2
7.578E-2
 5 267
40 GO:0048659 smooth muscle cell proliferation 5.119E-5 1.933E-3 1.526E-2
7.730E-2
 4 134
41 GO:0009411 response to UV 6.073E-5 2.209E-3 1.744E-2
9.170E-2
 4 140
42 GO:0001944 vasculature development 6.143E-5 2.209E-3 1.744E-2
9.277E-2
 7 680
43 GO:1901724 positive regulation of cell proliferation involved in kidney development 6.406E-5 2.250E-3 1.777E-2
9.674E-2
 2 8
44 GO:0071496 cellular response to external stimulus 7.793E-5 2.675E-3 2.112E-2
1.177E-1
 5 293
45 GO:0008285 negative regulation of cell proliferation 8.653E-5 2.904E-3 2.293E-2
1.307E-1
 7 718
46 GO:0051707 response to other organism 9.077E-5 2.916E-3 2.303E-2
1.371E-1
 8 988
47 GO:0043207 response to external biotic stimulus 9.077E-5 2.916E-3 2.303E-2
1.371E-1
 8 988
48 GO:0090183 regulation of kidney development 1.015E-4 3.192E-3 2.521E-2
1.532E-1
 3 59
49 GO:0071417 cellular response to organonitrogen compound 1.182E-4 3.642E-3 2.876E-2
1.785E-1
 6 518
50 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 1.294E-4 3.907E-3 3.085E-2
1.953E-1
 3 64
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 82 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005730 nucleolus 4.312E-6 1.680E-4 8.382E-4 3.536E-4 9 894
2 GO:0000785 chromatin 6.452E-6 1.680E-4 8.382E-4 5.291E-4 7 489
3 GO:0000790 nuclear chromatin 7.883E-6 1.680E-4 8.382E-4 6.464E-4 6 326
4 GO:0044451 nucleoplasm part 9.706E-6 1.680E-4 8.382E-4 7.959E-4 8 738
5 GO:0044454 nuclear chromosome part 1.132E-5 1.680E-4 8.382E-4 9.279E-4 7 533
6 GO:0005719 nuclear euchromatin 1.229E-5 1.680E-4 8.382E-4 1.008E-3 3 30
7 GO:0005667 transcription factor complex 1.594E-5 1.791E-4 8.938E-4 1.307E-3 6 369
8 GO:0000228 nuclear chromosome 1.748E-5 1.791E-4 8.938E-4 1.433E-3 7 570
9 GO:0000791 euchromatin 2.961E-5 2.698E-4 1.346E-3 2.428E-3 3 40
10 GO:0044427 chromosomal part 2.039E-4 1.536E-3 7.664E-3 1.672E-2 7 841
11 GO:0016604 nuclear body 2.060E-4 1.536E-3 7.664E-3 1.689E-2 5 368
12 GO:0005694 chromosome 4.101E-4 2.802E-3 1.398E-2 3.363E-2 7 943
13 GO:0032996 Bcl3-Bcl10 complex 1.515E-3 9.555E-3 4.768E-2
1.242E-1
 1 1
14 GO:0045171 intercellular bridge 2.101E-3 1.230E-2
6.140E-2
1.723E-1
 2 45
15 GO:0033257 Bcl3/NF-kappaB2 complex 3.023E-3 1.653E-2
8.246E-2
2.479E-1
 1 2
16 GO:0070603 SWI/SNF superfamily-type complex 5.578E-3 2.859E-2
1.427E-1
4.574E-1
 2 74
17 GO:0016602 CCAAT-binding factor complex 6.037E-3 2.912E-2
1.453E-1
4.951E-1
 1 4
18 GO:0017053 transcriptional repressor complex 6.489E-3 2.956E-2
1.475E-1
5.321E-1
 2 80
19 GO:0005726 perichromatin fibrils 7.541E-3 3.255E-2
1.624E-1
6.184E-1
 1 5
20 GO:0000798 nuclear cohesin complex 9.043E-3 3.518E-2
1.755E-1
7.415E-1
 1 6
21 GO:0034991 nuclear meiotic cohesin complex 9.043E-3 3.518E-2
1.755E-1
7.415E-1
 1 6
22 GO:0016605 PML body 9.977E-3 3.518E-2
1.755E-1
8.182E-1
 2 100
23 GO:0030893 meiotic cohesin complex 1.054E-2 3.518E-2
1.755E-1
8.644E-1
 1 7
24 GO:0008024 cyclin/CDK positive transcription elongation factor complex 1.054E-2 3.518E-2
1.755E-1
8.644E-1
 1 7
25 GO:0005819 spindle 1.102E-2 3.518E-2
1.755E-1
9.033E-1
 3 308
26 GO:0016363 nuclear matrix 1.115E-2 3.518E-2
1.755E-1
9.147E-1
 2 106
27 GO:0033256 I-kappaB/NF-kappaB complex 1.204E-2 3.656E-2
1.825E-1
9.872E-1
 1 8
28 GO:0000922 spindle pole 1.716E-2 4.763E-2
2.377E-1
1.000E0
 2 133
29 GO:0034399 nuclear periphery 1.789E-2 4.763E-2
2.377E-1
1.000E0
 2 136
30 GO:0008278 cohesin complex 1.801E-2 4.763E-2
2.377E-1
1.000E0
 1 12
31 GO:0071564 npBAF complex 1.801E-2 4.763E-2
2.377E-1
1.000E0
 1 12
32 GO:0031011 Ino80 complex 2.098E-2 4.915E-2
2.452E-1
1.000E0
 1 14
33 GO:0071565 nBAF complex 2.098E-2 4.915E-2
2.452E-1
1.000E0
 1 14
34 GO:0000800 lateral element 2.098E-2 4.915E-2
2.452E-1
1.000E0
 1 14
35 GO:0016580 Sin3 complex 2.098E-2 4.915E-2
2.452E-1
1.000E0
 1 14
36 GO:0016514 SWI/SNF complex 2.246E-2 4.970E-2
2.480E-1
1.000E0
 1 15
37 GO:0033202 DNA helicase complex 2.246E-2 4.970E-2
2.480E-1
1.000E0
 1 15
38 GO:0048471 perinuclear region of cytoplasm 2.303E-2 4.970E-2
2.480E-1
1.000E0
 4 728
Show 33 more annotations

4: Human Phenotype [Display Chart] 51 annotations before applied cutoff / 1813 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 1318 annotations before applied cutoff / 9208 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0003857 abnormal hindlimb zeugopod morphology 3.442E-5 2.876E-2
2.233E-1
 4.537E-2 6 251
2 MP:0005013 increased lymphocyte cell number 5.188E-5 2.876E-2
2.233E-1
6.837E-2
 9 730
3 MP:0000350 abnormal cell proliferation 6.547E-5 2.876E-2
2.233E-1
8.629E-2
 10 949
4 MP:0008156 decreased diameter of tibia 9.705E-5 3.198E-2
2.482E-1
1.279E-1
 2 6
5 MP:0000558 abnormal tibia morphology 2.850E-4 4.496E-2
3.489E-1
3.756E-1
 5 233
6 MP:0011704 decreased fibroblast proliferation 2.961E-4 4.496E-2
3.489E-1
3.903E-1
 4 127
7 MP:0010308 decreased tumor latency 2.985E-4 4.496E-2
3.489E-1
3.934E-1
 3 51
8 MP:0003948 abnormal gas homeostasis 3.087E-4 4.496E-2
3.489E-1
4.068E-1
 7 534
9 MP:0001828 abnormal T cell activation 3.252E-4 4.496E-2
3.489E-1
4.286E-1
 6 377
10 MP:0011705 absent fibroblast proliferation 3.530E-4 4.496E-2
3.489E-1
4.653E-1
 2 11
11 MP:0011091 prenatal lethality, complete penetrance 4.011E-4 4.496E-2
3.489E-1
5.287E-1
 6 392
12 MP:0001575 cyanosis 4.093E-4 4.496E-2
3.489E-1
5.395E-1
 5 252
13 MP:0000556 abnormal hindlimb morphology 4.530E-4 4.579E-2
3.554E-1
5.971E-1
 6 401
14 MP:0010593 thick aortic valve cusps 4.990E-4 4.579E-2
3.554E-1
6.577E-1
 2 13
15 MP:0002085 abnormal embryonic tissue morphology 5.211E-4 4.579E-2
3.554E-1
6.868E-1
 9 985
16 MP:0010602 abnormal pulmonary valve cusp morphology 5.813E-4 4.788E-2
3.716E-1
7.661E-1
 2 14
Show 11 more annotations

6: Domain [Display Chart] 212 annotations before applied cutoff / 16924 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF11928 DUF3446 Pfam 7.911E-6 3.354E-4 1.991E-3 1.677E-3 2 3
2 IPR021849 DUF3446 InterPro 7.911E-6 3.354E-4 1.991E-3 1.677E-3 2 3
3 PS51134 ZF TFIIB PROSITE 7.911E-6 3.354E-4 1.991E-3 1.677E-3 2 3
4 IPR000812 TFIIB-related InterPro 7.911E-6 3.354E-4 1.991E-3 1.677E-3 2 3
5 PS00782 TFIIB PROSITE 7.911E-6 3.354E-4 1.991E-3 1.677E-3 2 3
6 PF08271 TFIIB Zn Ribbon Pfam 1.581E-5 4.787E-4 2.841E-3 3.351E-3 2 4
7 IPR013137 Znf TFIIB InterPro 1.581E-5 4.787E-4 2.841E-3 3.351E-3 2 4
8 PF00010 HLH Pfam 2.854E-5 5.340E-4 3.170E-3 6.049E-3 4 108
9 SM00385 CYCLIN SMART 3.291E-5 5.340E-4 3.170E-3 6.977E-3 3 38
10 IPR006670 Cyclin InterPro 3.291E-5 5.340E-4 3.170E-3 6.977E-3 3 38
11 PS50888 HLH PROSITE 3.409E-5 5.340E-4 3.170E-3 7.227E-3 4 113
12 G3DSA:4.10.280.10 HLH DNA bd Gene3D 3.409E-5 5.340E-4 3.170E-3 7.227E-3 4 113
13 SM00353 HLH SMART 3.529E-5 5.340E-4 3.170E-3 7.481E-3 4 114
14 IPR011598 HLH DNA-bd InterPro 3.652E-5 5.340E-4 3.170E-3 7.742E-3 4 115
15 IPR001092 HLH DNA-bd dom InterPro 3.778E-5 5.340E-4 3.170E-3 8.010E-3 4 116
16 G3DSA:1.10.472.10 Cyclin related Gene3D 4.145E-5 5.492E-4 3.260E-3 8.788E-3 3 41
17 IPR013763 Cyclin-related InterPro 4.459E-5 5.561E-4 3.301E-3 9.453E-3 3 42
18 IPR011028 Cyclin-like InterPro 7.101E-5 8.363E-4 4.965E-3 1.505E-2 3 49
19 IPR013087 Znf C2H2/integrase DNA-bd InterPro 6.162E-4 6.584E-3 3.909E-2
1.306E-1
 6 659
20 G3DSA:3.30.160.60 Znf C2H2/integrase DNA-bd Gene3D 6.212E-4 6.584E-3 3.909E-2
1.317E-1
 6 660
21 PF00096 zf-C2H2 Pfam 6.992E-4 7.059E-3 4.190E-2
1.482E-1
 6 675
22 PS50157 ZINC FINGER C2H2 2 PROSITE 1.279E-3 8.561E-3
5.082E-2
2.712E-1
 6 758
23 PS00028 ZINC FINGER C2H2 1 PROSITE 1.297E-3 8.561E-3
5.082E-2
2.749E-1
 6 760
24 IPR015880 Znf C2H2-like InterPro 1.323E-3 8.561E-3
5.082E-2
2.805E-1
 6 763
25 PF00170 bZIP 1 Pfam 1.433E-3 8.561E-3
5.082E-2
3.038E-1
 2 34
26 IPR011616 bZIP 1 InterPro 1.433E-3 8.561E-3
5.082E-2
3.038E-1
 2 34
27 IPR007087 Znf C2H2 InterPro 1.551E-3 8.561E-3
5.082E-2
3.289E-1
 6 787
28 SM00355 ZnF C2H2 SMART 1.572E-3 8.561E-3
5.082E-2
3.332E-1
 6 789
29 PS51152 NFYA HAP2 2 PROSITE 1.657E-3 8.561E-3
5.082E-2
3.513E-1
 1 1
30 IPR001289 TF CBFB InterPro 1.657E-3 8.561E-3
5.082E-2
3.513E-1
 1 1
31 PS00686 NFYA HAP2 1 PROSITE 1.657E-3 8.561E-3
5.082E-2
3.513E-1
 1 1
32 IPR015558 C Jun InterPro 1.657E-3 8.561E-3
5.082E-2
3.513E-1
 1 1
33 PF02045 CBFB NFYA Pfam 1.657E-3 8.561E-3
5.082E-2
3.513E-1
 1 1
34 IPR022752 STAT1 TAZ2-bd C InterPro 1.657E-3 8.561E-3
5.082E-2
3.513E-1
 1 1
35 IPR018362 CCAAT-binding factor CS InterPro 1.657E-3 8.561E-3
5.082E-2
3.513E-1
 1 1
36 PF12162 STAT1 TAZ2bind Pfam 1.657E-3 8.561E-3
5.082E-2
3.513E-1
 1 1
37 SM00521 CBF SMART 1.657E-3 8.561E-3
5.082E-2
3.513E-1
 1 1
38 IPR003327 Myc-LZ InterPro 1.657E-3 8.561E-3
5.082E-2
3.513E-1
 1 1
39 PF11914 DUF3432 Pfam 1.657E-3 8.561E-3
5.082E-2
3.513E-1
 1 1
40 PF02344 Myc-LZ Pfam 1.657E-3 8.561E-3
5.082E-2
3.513E-1
 1 1
41 IPR021839 DUF3432 InterPro 1.657E-3 8.561E-3
5.082E-2
3.513E-1
 1 1
42 IPR008917 Euk TF DNA-bd InterPro 1.696E-3 8.561E-3
5.082E-2
3.596E-1
 2 37
43 IPR016311 Transforming factor C-ets InterPro 3.306E-3 1.259E-2
7.474E-2
7.009E-1
 1 2
44 IPR017114 TF Yin yang InterPro 3.306E-3 1.259E-2
7.474E-2
7.009E-1
 1 2
45 PF08295 HDAC interact Pfam 3.306E-3 1.259E-2
7.474E-2
7.009E-1
 1 2
46 IPR015430 Cyclin T InterPro 3.306E-3 1.259E-2
7.474E-2
7.009E-1
 1 2
47 SM00951 QLQ SMART 3.306E-3 1.259E-2
7.474E-2
7.009E-1
 1 2
48 SM00438 ZnF NFX SMART 3.306E-3 1.259E-2
7.474E-2
7.009E-1
 1 2
49 IPR013150 TFIIB cyclin InterPro 3.306E-3 1.259E-2
7.474E-2
7.009E-1
 1 2
50 IPR014978 Gln-Leu-Gln QLQ InterPro 3.306E-3 1.259E-2
7.474E-2
7.009E-1
 1 2
Show 45 more annotations

7: Pathway [Display Chart] 509 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 P00046 Oxidative stress response PantherDB 2.652E-8 1.350E-5 9.194E-5 1.350E-5 5 46
2 138014 Glucocorticoid receptor regulatory network BioSystems: Pathway Interaction Database 5.037E-7 8.624E-5 5.873E-4 2.564E-4 5 82
3 198893 p38 MAPK Signaling Pathway BioSystems: WikiPathways 5.514E-7 8.624E-5 5.873E-4 2.807E-4 4 34
4 M13863 MAPKinase Signaling Pathway MSigDB C2 BIOCARTA (v5.1) 6.777E-7 8.624E-5 5.873E-4 3.450E-4 5 87
5 M862 p38 MAPK Signaling Pathway MSigDB C2 BIOCARTA (v5.1) 1.078E-6 1.097E-4 7.475E-4 5.487E-4 4 40
6 137932 IL6-mediated signaling events BioSystems: Pathway Interaction Database 1.450E-6 1.230E-4 8.378E-4 7.381E-4 4 43
7 755440 Prostate Cancer BioSystems: WikiPathways 2.082E-6 1.445E-4 9.842E-4 1.060E-3 5 109
8 137993 Calcineurin-regulated NFAT-dependent transcription in lymphocytes BioSystems: Pathway Interaction Database 2.271E-6 1.445E-4 9.842E-4 1.156E-3 4 48
9 137976 IL2-mediated signaling events BioSystems: Pathway Interaction Database 3.143E-6 1.778E-4 1.211E-3 1.600E-3 4 52
10 193147 Osteoclast differentiation BioSystems: KEGG 5.350E-6 2.631E-4 1.792E-3 2.723E-3 5 132
11 M14449 METS affect on Macrophage Differentiation MSigDB C2 BIOCARTA (v5.1) 5.686E-6 2.631E-4 1.792E-3 2.894E-3 3 18
12 672446 TSH signaling pathway BioSystems: WikiPathways 7.261E-6 2.987E-4 2.034E-3 3.696E-3 4 64
13 712093 BDNF signaling pathway BioSystems: WikiPathways 8.190E-6 2.987E-4 2.034E-3 4.169E-3 5 144
14 137987 Regulation of Telomerase BioSystems: Pathway Interaction Database 8.215E-6 2.987E-4 2.034E-3 4.181E-3 4 66
15 P04393 Ras Pathway PantherDB 9.258E-6 3.142E-4 2.140E-3 4.712E-3 4 68
16 373901 HTLV-I infection BioSystems: KEGG 9.965E-6 3.170E-4 2.159E-3 5.072E-3 6 263
17 219801 Integrated Breast Cancer Pathway BioSystems: WikiPathways 1.136E-5 3.212E-4 2.188E-3 5.782E-3 5 154
18 198774 TGF-beta Receptor Signaling Pathway BioSystems: WikiPathways 1.136E-5 3.212E-4 2.188E-3 5.782E-3 5 154
19 M7897 Inhibition of Cellular Proliferation by Gleevec MSigDB C2 BIOCARTA (v5.1) 1.226E-5 3.284E-4 2.237E-3 6.240E-3 3 23
20 672462 Prolactin Signaling Pathway BioSystems: WikiPathways 1.369E-5 3.484E-4 2.373E-3 6.968E-3 4 75
21 137963 Regulation of nuclear SMAD2/3 signaling BioSystems: Pathway Interaction Database 1.600E-5 3.879E-4 2.642E-3 8.145E-3 4 78
22 198782 EGFR1 Signaling Pathway BioSystems: WikiPathways 2.230E-5 5.160E-4 3.514E-3 1.135E-2 5 177
23 138061 CD40/CD40L signaling BioSystems: Pathway Interaction Database 2.785E-5 6.163E-4 4.197E-3 1.418E-2 3 30
24 711360 Integrated Pancreatic Cancer Pathway BioSystems: WikiPathways 3.467E-5 7.354E-4 5.008E-3 1.765E-2 5 194
25 585562 Epstein-Barr virus infection BioSystems: KEGG 4.309E-5 8.408E-4 5.727E-3 2.193E-2 5 203
26 198847 Wnt Signaling Pathway and Pluripotency BioSystems: WikiPathways 4.443E-5 8.408E-4 5.727E-3 2.262E-2 4 101
27 138012 Signaling mediated by p38-alpha and p38-beta BioSystems: Pathway Interaction Database 4.460E-5 8.408E-4 5.727E-3 2.270E-2 3 35
28 138057 ErbB1 downstream signaling BioSystems: Pathway Interaction Database 4.799E-5 8.723E-4 5.941E-3 2.443E-2 4 103
29 672451 TSLP Signaling Pathway BioSystems: WikiPathways 5.726E-5 1.005E-3 6.845E-3 2.915E-2 3 38
30 198885 IL-2 Signaling pathway BioSystems: WikiPathways 7.752E-5 1.315E-3 8.958E-3 3.946E-2 3 42
31 M2579 Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. MSigDB C2 BIOCARTA (v5.1) 9.545E-5 1.567E-3 1.067E-2 4.858E-2 3 45
32 M19118 Keratinocyte Differentiation MSigDB C2 BIOCARTA (v5.1) 1.020E-4 1.622E-3 1.105E-2
5.190E-2
 3 46
33 P00047 PDGF signaling pathway PantherDB 1.087E-4 1.676E-3 1.141E-2
5.531E-2
 4 127
34 920993 Interferon type I BioSystems: WikiPathways 1.233E-4 1.846E-3 1.257E-2
6.275E-2
 3 49
35 138018 Downstream signaling in naive CD8+ T cells BioSystems: Pathway Interaction Database 1.310E-4 1.852E-3 1.261E-2
6.667E-2
 3 50
36 138027 Regulation of Androgen receptor activity BioSystems: Pathway Interaction Database 1.310E-4 1.852E-3 1.261E-2
6.667E-2
 3 50
37 M19336 Type I Interferon (alpha/beta IFN) Pathway MSigDB C2 BIOCARTA (v5.1) 1.384E-4 1.904E-3 1.297E-2
7.045E-2
 2 9
38 755437 Type III interferon signaling BioSystems: WikiPathways 1.728E-4 2.255E-3 1.536E-2
8.795E-2
 2 10
39 160139 Activation of the AP-1 family of transcription factors BioSystems: REACTOME 1.728E-4 2.255E-3 1.536E-2
8.795E-2
 2 10
40 137916 Regulation of retinoblastoma protein BioSystems: Pathway Interaction Database 1.838E-4 2.312E-3 1.575E-2
9.355E-2
 3 56
41 694606 Hepatitis B BioSystems: KEGG 1.862E-4 2.312E-3 1.575E-2
9.479E-2
 4 146
42 P00005 Angiogenesis PantherDB 2.066E-4 2.504E-3 1.706E-2
1.052E-1
 4 150
43 198789 Wnt Signaling Pathway BioSystems: WikiPathways 2.257E-4 2.672E-3 1.820E-2
1.149E-1
 3 60
44 169353 Validated targets of C-MYC transcriptional repression BioSystems: Pathway Interaction Database 2.488E-4 2.878E-3 1.960E-2
1.266E-1
 3 62
45 137933 IL4-mediated signaling events BioSystems: Pathway Interaction Database 2.609E-4 2.887E-3 1.966E-2
1.328E-1
 3 63
46 711361 Oncostatin M Signaling Pathway BioSystems: WikiPathways 2.609E-4 2.887E-3 1.966E-2
1.328E-1
 3 63
47 198760 IL-4 signaling Pathway BioSystems: WikiPathways 2.734E-4 2.961E-3 2.016E-2
1.391E-1
 3 64
48 M14339 Oxidative Stress Induced Gene Expression Via Nrf2 MSigDB C2 BIOCARTA (v5.1) 2.984E-4 2.982E-3 2.031E-2
1.519E-1
 2 13
49 698754 AGE/RAGE pathway BioSystems: WikiPathways 2.995E-4 2.982E-3 2.031E-2
1.524E-1
 3 66
50 187104 Interferon alpha/beta signaling BioSystems: REACTOME 2.995E-4 2.982E-3 2.031E-2
1.524E-1
 3 66
Show 45 more annotations

8: Pubmed [Display Chart] 11808 annotations before applied cutoff / 51818 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Pubmed 5.583E-18 6.592E-14 6.562E-13 6.592E-14 14 849
2 24952347 DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: role of the DNMT3L/DNMT3B/p65-NF¿B complex in the (de-)methylation of TRAF1. Pubmed 1.377E-14 8.130E-11 8.092E-10 1.626E-10 7 74
3 9184233 Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor. Pubmed 2.764E-12 1.088E-8 1.083E-7 3.264E-8 4 7
4 20936779 A human MAP kinase interactome. Pubmed 2.042E-10 6.027E-7 5.999E-6 2.411E-6 8 486
5 9528857 Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc. Pubmed 3.047E-10 7.196E-7 7.163E-6 3.598E-6 4 19
6 16195385 Apical role for BRG1 in cytokine-induced promoter assembly. Pubmed 1.575E-9 2.066E-6 2.056E-5 1.859E-5 3 5
7 9160889 Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity. Pubmed 1.575E-9 2.066E-6 2.056E-5 1.859E-5 3 5
8 19231233:gr Cytokine production through PKC/p38 signaling pathways, not through JAK/STAT1 pathway, in mast cells stimulated with IFNgamma. GeneRIF 1.575E-9 2.066E-6 2.056E-5 1.859E-5 3 5
9 16126174 Six lysine residues on c-Myc are direct substrates for acetylation by p300. Pubmed 1.575E-9 2.066E-6 2.056E-5 1.859E-5 3 5
10 20398657 The steroid receptor RNA activator protein is recruited to promoter regions and acts as a transcriptional repressor. Pubmed 2.462E-9 2.907E-6 2.894E-5 2.907E-5 4 31
11 15467743 Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential. Pubmed 3.148E-9 3.379E-6 3.364E-5 3.717E-5 3 6
12 15358760 Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. Pubmed 8.808E-9 7.429E-6 7.395E-5 1.040E-4 3 8
13 11438660 A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A. Pubmed 8.808E-9 7.429E-6 7.395E-5 1.040E-4 3 8
14 16878156 Cooperation between Myc and YY1 provides novel silencing transcriptional targets of alpha3beta1-integrin in tumour cells. Pubmed 8.808E-9 7.429E-6 7.395E-5 1.040E-4 3 8
15 19231233 Cytokine production through PKC/p38 signaling pathways, not through JAK/STAT1 pathway, in mast cells stimulated with IFNgamma. Pubmed 1.886E-8 1.485E-5 1.478E-4 2.227E-4 3 10
16 10593926 Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors. Pubmed 2.592E-8 1.913E-5 1.904E-4 3.061E-4 3 11
17 17082780 Proteomic discovery of Max as a novel interacting partner of C/EBPalpha: a Myc/Max/Mad link. Pubmed 5.712E-8 3.550E-5 3.534E-4 6.745E-4 3 14
18 9155018 MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. Pubmed 5.712E-8 3.550E-5 3.534E-4 6.745E-4 3 14
19 17827154 Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. Pubmed 5.712E-8 3.550E-5 3.534E-4 6.745E-4 3 14
20 20195357 A comprehensive resource of interacting protein regions for refining human transcription factor networks. Pubmed 6.594E-8 3.831E-5 3.813E-4 7.786E-4 5 188
21 15674325 PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation. Pubmed 7.138E-8 3.831E-5 3.813E-4 8.428E-4 3 15
22 12391307 JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors. Pubmed 7.138E-8 3.831E-5 3.813E-4 8.428E-4 3 15
23 14559996 mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad. Pubmed 1.279E-7 4.962E-5 4.939E-4 1.510E-3 3 18
24 10229200 Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc. Pubmed 1.518E-7 4.962E-5 4.939E-4 1.792E-3 3 19
25 15302935 Large-scale characterization of HeLa cell nuclear phosphoproteins. Pubmed 1.877E-7 4.962E-5 4.939E-4 2.216E-3 7 773
26 19332535:gr Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus. GeneRIF 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
27 7565735 Correlation of two-hybrid affinity data with in vitro measurements. Pubmed 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
28 24657798 Small-molecule inhibitors of the Myc oncoprotein. Pubmed 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
29 16201965:gr Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function. GeneRIF 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
30 19389701:gr Target gene specificity of USF-1 is directed via p38-mediated phosphorylation-dependent acetylation. GeneRIF 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
31 22169291:gr [Effects of DLL4 gene on YY1 and c-Myc protein expression and cell proliferation in leukemia cell line K562]. GeneRIF 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
32 22733550 New structural determinants for c-Myc specific heterodimerization with Max and development of a novel homodimeric c-Myc b-HLH-LZ. Pubmed 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
33 17726060 P-STAT1 mediates higher-order chromatin remodelling of the human MHC in response to IFNgamma. Pubmed 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
34 15121849 Visualization of Myc/Max/Mad family dimers and the competition for dimerization in living cells. Pubmed 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
35 20436908:gr Functional crosstalk between type I and II interferon through the regulated expression of STAT1. GeneRIF 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
36 7479834 Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein. Pubmed 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
37 19781349:gr [Study of the relationship between early growth response gene 1 activity in p38 mitogen-activated protein kinase pathway and epirubicin resistance of human breast carcinoma cells]. GeneRIF 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
38 16201965 Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function. Pubmed 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
39 19837979 Identification of early growth response protein 1 (EGR-1) as a novel target for JUN-induced apoptosis in multiple myeloma. Pubmed 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
40 8266081 Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc. Pubmed 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
41 19251936:gr Fra-1 negatively regulates lipopolysaccharide-mediated inflammatory responses. GeneRIF 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
42 21697347 Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3. Pubmed 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
43 21173153:gr EGR1 and EGR2 involvement in vertebrate tendon differentiation. GeneRIF 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
44 25522242 Pubmed 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
45 18435914:gr ERK signaling regulates tumor promoter induced c-Jun recruitment at the Fra-1 promoter. GeneRIF 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
46 15809730 Mxi1 isoforms are expressed in hematological cell lines and normal bone marrow. Pubmed 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
47 22306690:gr Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling. GeneRIF 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
48 20511396:gr In situ proximity ligation detection of c-Jun/AP-1 dimers reveals increased levels of c-Jun/Fra1 complexes in aggressive breast cancer cell lines in vitro and in vivo. GeneRIF 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
49 24685915 MYC and MXI1 protein expression: potential prognostic significance in women with breast cancer in China. Pubmed 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
50 19781349 [Study of the relationship between early growth response gene 1 activity in p38 mitogen-activated protein kinase pathway and epirubicin resistance of human breast carcinoma cells]. Pubmed 3.026E-7 4.962E-5 4.939E-4 3.573E-3 2 2
Show 45 more annotations

9: Interaction [Display Chart] 2026 annotations before applied cutoff / 16535 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:EP300 EP300 interactions 2.349E-14 4.759E-11 3.898E-10 4.759E-11 14 501
2 int:TBP TBP interactions 3.595E-13 2.636E-10 2.160E-9 7.284E-10 10 183
3 int:JUN JUN interactions 3.904E-13 2.636E-10 2.160E-9 7.909E-10 11 265
4 int:SP1 SP1 interactions 1.197E-11 6.065E-9 4.968E-8 2.426E-8 10 260
5 int:CREBBP CREBBP interactions 1.509E-11 6.113E-9 5.007E-8 3.056E-8 11 371
6 int:HDAC1 HDAC1 interactions 5.152E-11 1.740E-8 1.425E-7 1.044E-7 12 551
7 int:DNMT3L DNMT3L interactions 1.142E-10 3.305E-8 2.708E-7 2.314E-7 7 86
8 int:SMARCA4 SMARCA4 interactions 2.850E-10 7.218E-8 5.913E-7 5.774E-7 9 251
9 int:JUNB JUNB interactions 3.228E-10 7.266E-8 5.952E-7 6.539E-7 6 52
10 int:MAX MAX interactions 4.421E-10 8.826E-8 7.230E-7 8.957E-7 7 104
11 int:MXI1 MXI1 interactions 4.792E-10 8.826E-8 7.230E-7 9.709E-7 5 24
12 int:ESR1 ESR1 interactions 1.997E-9 3.371E-7 2.761E-6 4.045E-6 12 758
13 int:SMARCA5 SMARCA5 interactions 2.374E-9 3.699E-7 3.030E-6 4.809E-6 7 132
14 int:SIN3A SIN3A interactions 3.025E-9 4.377E-7 3.585E-6 6.128E-6 8 221
15 int:HDAC3 HDAC3 interactions 3.363E-9 4.543E-7 3.721E-6 6.814E-6 8 224
16 int:NFATC1 NFATC1 interactions 4.267E-9 5.403E-7 4.426E-6 8.645E-6 6 79
17 int:CEBPB CEBPB interactions 1.228E-8 1.463E-6 1.198E-5 2.487E-5 6 94
18 int:HCFC1 HCFC1 interactions 2.837E-8 3.194E-6 2.616E-5 5.748E-5 6 108
19 int:KAT2B KAT2B interactions 3.569E-8 3.806E-6 3.117E-5 7.231E-5 7 195
20 int:SMARCA2 SMARCA2 interactions 5.339E-8 5.408E-6 4.430E-5 1.082E-4 6 120
21 int:CEBPA CEBPA interactions 6.134E-8 5.918E-6 4.848E-5 1.243E-4 7 211
22 int:CSNK2A1 CSNK2A1 interactions 7.552E-8 6.381E-6 5.227E-5 1.530E-4 9 476
23 int:HDAC9 HDAC9 interactions 7.559E-8 6.381E-6 5.227E-5 1.531E-4 5 63
24 int:USF1 USF1 interactions 7.559E-8 6.381E-6 5.227E-5 1.531E-4 5 63
25 int:MAF MAF interactions 9.408E-8 7.624E-6 6.245E-5 1.906E-4 4 25
26 int:MECP2 MECP2 interactions 1.034E-7 8.054E-6 6.597E-5 2.094E-4 5 67
27 int:L3MBTL2 L3MBTL2 interactions 1.114E-7 8.361E-6 6.849E-5 2.257E-4 5 68
28 int:PML PML interactions 1.281E-7 9.268E-6 7.592E-5 2.595E-4 7 235
29 int:MXD4 MXD4 interactions 1.690E-7 1.167E-5 9.561E-5 3.423E-4 3 7
30 int:SMAD3 SMAD3 interactions 1.728E-7 1.167E-5 9.561E-5 3.502E-4 8 372
31 int:MXD1 MXD1 interactions 2.026E-7 1.324E-5 1.084E-4 4.104E-4 4 30
32 int:CREB1 CREB1 interactions 2.543E-7 1.610E-5 1.319E-4 5.151E-4 6 156
33 int:MXD3 MXD3 interactions 2.700E-7 1.658E-5 1.358E-4 5.471E-4 3 8
34 int:FOSL1 FOSL1 interactions 3.014E-7 1.796E-5 1.471E-4 6.106E-4 4 33
35 int:FOS FOS interactions 3.801E-7 2.200E-5 1.802E-4 7.701E-4 6 167
36 int:FOXP3 FOXP3 interactions 4.598E-7 2.562E-5 2.099E-4 9.316E-4 8 423
37 int:NCOR1 NCOR1 interactions 4.679E-7 2.562E-5 2.099E-4 9.479E-4 6 173
38 int:STAT1 STAT1 interactions 8.109E-7 4.226E-5 3.461E-4 1.643E-3 6 190
39 int:GTF2B GTF2B interactions 8.135E-7 4.226E-5 3.461E-4 1.648E-3 5 101
40 int:SRA1 SRA1 interactions 8.980E-7 4.548E-5 3.726E-4 1.819E-3 4 43
41 int:EPAS1 EPAS1 interactions 9.410E-7 4.571E-5 3.744E-4 1.906E-3 5 104
42 int:RELA RELA interactions 9.475E-7 4.571E-5 3.744E-4 1.920E-3 7 316
43 int:NCOA1 NCOA1 interactions 1.188E-6 5.598E-5 4.586E-4 2.407E-3 5 109
44 int:BCL3 BCL3 interactions 1.292E-6 5.947E-5 4.872E-4 2.617E-3 4 47
45 int:NR5A1 NR5A1 interactions 1.407E-6 6.336E-5 5.190E-4 2.851E-3 4 48
46 int:IRF1 IRF1 interactions 1.662E-6 7.319E-5 5.995E-4 3.367E-3 4 50
47 int:ATF2 ATF2 interactions 1.713E-6 7.356E-5 6.026E-4 3.471E-3 6 216
48 int:MNT MNT interactions 1.743E-6 7.356E-5 6.026E-4 3.531E-3 3 14
49 int:BCL6 BCL6 interactions 1.835E-6 7.588E-5 6.215E-4 3.718E-3 5 119
50 int:EGR1 EGR1 interactions 2.105E-6 8.530E-5 6.987E-4 4.265E-3 4 53
Show 45 more annotations

10: Cytoband [Display Chart] 27 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 10q24-q25 10q24-q25 3.228E-3 2.478E-2
9.644E-2
8.714E-2
 1 4
2 6p21.3-p21.2 6p21.3-p21.2 3.228E-3 2.478E-2
9.644E-2
8.714E-2
 1 4
3 10q22-q23 10q22-q23 4.033E-3 2.478E-2
9.644E-2
1.089E-1
 1 5
4 1p22-p21 1p22-p21 4.033E-3 2.478E-2
9.644E-2
1.089E-1
 1 5
5 14q23 14q23 7.248E-3 2.478E-2
9.644E-2
1.957E-1
 1 9
6 19q13.1-q13.2 19q13.1-q13.2 7.248E-3 2.478E-2
9.644E-2
1.957E-1
 1 9
7 1p32-p31 1p32-p31 8.050E-3 2.478E-2
9.644E-2
2.173E-1
 1 10
8 6q22-q23 6q22-q23 8.050E-3 2.478E-2
9.644E-2
2.173E-1
 1 10
9 10q25 10q25 8.852E-3 2.478E-2
9.644E-2
2.390E-1
 1 11
10 1q22-q23 1q22-q23 1.045E-2 2.478E-2
9.644E-2
2.822E-1
 1 13
11 8p11.23 8p11.23 1.045E-2 2.478E-2
9.644E-2
2.822E-1
 1 13
12 2q32.2 2q32.2 1.205E-2 2.478E-2
9.644E-2
3.254E-1
 1 15
13 2q21.3 2q21.3 1.205E-2 2.478E-2
9.644E-2
3.254E-1
 1 15
14 8q24.21 8q24.21 1.285E-2 2.478E-2
9.644E-2
3.469E-1
 1 16
15 19p13.2 19p13.2 1.541E-2 2.773E-2
1.079E-1
4.160E-1
 2 235
16 10q21.1 10q21.1 1.683E-2 2.841E-2
1.105E-1
4.545E-1
 1 21
17 8p11.21 8p11.21 1.842E-2 2.926E-2
1.139E-1
4.974E-1
 1 23
18 8q22.2 8q22.2 2.001E-2 3.001E-2
1.168E-1
5.402E-1
 1 25
19 15q24.2 15q24.2 2.633E-2 3.741E-2
1.456E-1
7.109E-1
 1 33
Show 14 more annotations

11: Transcription Factor Binding Site [Display Chart] 338 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$NFMUE1 Q6 V$NFMUE1 Q6 1.127E-4 3.307E-2
2.117E-1
 3.810E-2 5 194
2 V$SRF 01 V$SRF 01 1.957E-4 3.307E-2
2.117E-1
6.613E-2
 3 45

12: Gene Family [Display Chart] 3 annotations before applied cutoff / 6751 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 KLF Kruppel-like factors genenames.org 3.571E-5 1.071E-4 1.964E-4 1.071E-4 2 17
2 MXD MAX dimerization proteins genenames.org 3.551E-3 3.551E-3 6.510E-3 1.065E-2 1 6
3 SMC Structural maintenance of chromosomes proteins genenames.org 3.551E-3 3.551E-3 6.510E-3 1.065E-2 1 6

13: Coexpression [Display Chart] 2997 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M16311 Genes up-regulated in MCF7 cells (breast cancer) after stimulation with EGF [GeneID=1950]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.209E-10 3.623E-7 3.110E-6 3.623E-7 6 58
2 M5890 Genes regulated by NF-kB in response to TNF [GeneID=7124]. MSigDB H: Hallmark Gene Sets (v5.1) 6.343E-9 9.505E-6 8.158E-5 1.901E-5 7 200
3 M11585 Genes up-regulated in MCF7 cells (breast cancer) after stimulation with NRG1 [GeneID=3084]. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.830E-8 8.760E-5 7.518E-4 2.946E-4 6 175
4 M11218 Examples of transcription factors whose activities are regulated by MAPK7 [GeneID=5598] phosphorylation. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.169E-7 8.760E-5 7.518E-4 3.504E-4 3 8
5 M17211 Transcription factors down-regulated in LNCaP cells (prostate cancer) by expression of GR [GeneID=2908] off a lentiviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.501E-7 1.249E-4 1.072E-3 7.495E-4 3 10
6 M13038 List of the transcription factors up-regulated 1 hr after wounding HDF cells (dermal fibroblasts). MSigDB C2: CGP Curated Gene Sets (v5.1) 2.501E-7 1.249E-4 1.072E-3 7.495E-4 3 10
7 M7928 Genes up-regulated in the MM1S cells (multiple myeloma) after treatment with aplidin [PubChem=44152164], a marine-derived compound with potential anti-cancer properties. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.335E-6 4.556E-4 3.910E-3 4.000E-3 7 439
8 M2496 Genes up-regulated in Calu-6 cells (lung cancer) at 1 h time point after TNF [GeneID=7124] treatment. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.407E-6 4.556E-4 3.910E-3 4.218E-3 4 63
9 M2828 Genes down-regulated in SH-SY5Y cells (neuroblastoma) in response to PDGF [Gene ID=] stimulation after pre-treatment with the ERK inhibitors U0126 and PD98059 [PubChem=3006531, 4713]. MSigDB C6: Oncogenic Signatures (v5.1) 1.429E-6 4.556E-4 3.910E-3 4.283E-3 5 149
10 M6752 Genes essential to the development of megakaryocytes, as expressed in normal cells and essential thrombocythemic cells (ET). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.698E-6 4.556E-4 3.910E-3 5.089E-3 4 66
11 M13941 Clusters 1 and 2: genes up-regulated in B2264-19/3 cells (primary B lymphocytes) within 30-60 min after activation of LMP1 (an oncogene encoded by Epstein-Barr virus, EBV). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.698E-6 4.556E-4 3.910E-3 5.089E-3 4 66
12 M2858 Genes up-regulated in NOMO-1 and SKM-1 cells (AML) after knockdown of STK33 [Gene ID=65975] by RNAi. MSigDB C6: Oncogenic Signatures (v5.1) 1.824E-6 4.556E-4 3.910E-3 5.467E-3 6 288
13 M6822 Genes down-regulated in HMLE cells (mmortalized nontransformed mammary epithelial) by expression of a dominant-negative form of E-cadhedrin (CDH1) [GeneID=999]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.656E-6 6.122E-4 5.254E-3 7.959E-3 5 169
14 M14666 Genes modulated in HeLa cells (cervical carcinoma) by TNF [GeneID=7124] not via NFKB pathway. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.175E-6 6.797E-4 5.834E-3 9.516E-3 3 22
15 M15537 Genes from the turquoise module which are up-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphocholine (oxPAPC). MSigDB C2: CGP Curated Gene Sets (v5.1) 3.498E-6 6.990E-4 5.999E-3 1.048E-2 4 79
16 GSE18281 CORTICAL VS MEDULLARY THYMOCYTE UP Genes up-regulated in thymocytes: cortical versus medullary sources. MSigDB C7: Immunologic Signatures (v5.1) 5.902E-6 9.539E-4 8.187E-3 1.769E-2 5 199
17 M5776 Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from healthy donors versus PBMCs from patients with type 1 diabetes at the time of diagnosis. MSigDB C7: Immunologic Signatures (v5.1) 5.902E-6 9.539E-4 8.187E-3 1.769E-2 5 199
18 M5850 Genes up-regulated in comparison of monocytes treated with anti-TREM1 [GeneID=54210] versus monocytes treated with control IgG. MSigDB C7: Immunologic Signatures (v5.1) 5.902E-6 9.539E-4 8.187E-3 1.769E-2 5 199
19 M4117 Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 12 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 24 h. MSigDB C7: Immunologic Signatures (v5.1) 6.047E-6 9.539E-4 8.187E-3 1.812E-2 5 200
20 M1376 Genes down-regulated in MMH-RT cells (hepatocytes displaying an invasive, metastatic phenotype) during epithelial to mesenchymal transition (EMT). MSigDB C2: CGP Curated Gene Sets (v5.1) 6.982E-6 1.011E-3 8.677E-3 2.093E-2 5 206
21 M1885 Genes down-regulated in vascular smooth muscle cells (VSMC) by MAPK8 (JNK1) [GeneID=5599]. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.239E-6 1.011E-3 8.677E-3 2.170E-2 6 366
22 M6782 Genes up-regulated in T24 (bladder cancer) cells in response to the photodynamic therapy (PDT) stress. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.421E-6 1.011E-3 8.677E-3 2.224E-2 8 811
23 M9128 Genes up-regulated in UB27 cells (osteosarcoma) at any time point after inducing the expression of a mutant form of WT1 [GeneID=7490]. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.401E-6 1.095E-3 9.396E-3 2.518E-2 5 214
24 M13453 Genes up-regulated in HT1080 (fibrosarcoma) cells by treatment with interferon beta for 6 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.688E-6 1.210E-3 1.038E-2 2.904E-2 4 102
25 M1592 Genes up-regulated in 3T3-L1 cells (adipocyte) by insulin [GeneID=3630] which continued to respond normally to insulin in the insulin resistant cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.221E-5 1.463E-3 1.256E-2 3.658E-2 3 34
26 M3346 Genes down-regulated in HCT8/S11 cells (colon cancer) which lack DCC [GeneID=9423] and stably express NTN1 [GeneID=1630]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.334E-5 1.538E-3 1.320E-2 3.998E-2 3 35
27 M14072 Genes regulated by hypoxia, based on literature searches. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.523E-5 1.690E-3 1.451E-2 4.563E-2 5 242
28 M347 Oxidative stress genes down-regulated in ARPE-19 cells (retinal pigmented epithelium) in response to HNE and H2O2 [PubChem=5283344;784]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.856E-5 1.987E-3 1.705E-2
5.562E-2
 3 39
29 M15693 Cluster d8: genes progressively down-regulated in WS1 cells (fibroblast) through 18 h after irradiation with high dose UV-C. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.005E-5 2.072E-3 1.778E-2
6.008E-2
 3 40
30 M9905 Genes downregulated in peripheral blood lymphocytes (PBL) from patients with well functioning kidneys more than 1-year post transplant compared to those from normal living kidney donors. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.161E-5 2.159E-3 1.853E-2
6.476E-2
 3 41
31 M4204 Genes whose expression peaked at 40 min after stimulation of HeLa cells with EGF [GeneID=1950]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.325E-5 2.248E-3 1.929E-2
6.968E-2
 3 42
32 M14973 Genes up-regulated in U2OS cells (osteosarcoma) upon knockdown of HDAC1 [GeneID=3065] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.546E-5 2.385E-3 2.047E-2
7.632E-2
 6 457
33 M12391 Top 50 genes up-regulated in A549 cells (lung cancer) expressing STAT3 [GeneID=6774] off an adenovirus vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.708E-5 3.322E-3 2.851E-2
1.111E-1
 3 49
34 M8244 Genes changed in INA-6 cells (multiple myeloma, MM) by re-addition of IL6 [GeneID=3569] after its initial withdrawal for 12h. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.769E-5 3.322E-3 2.851E-2
1.130E-1
 4 144
35 M2696 Genes up-regulated in HEK293 cells (kidney fibroblasts) upon knockdown of RELA [Gene ID=5970] gene by RNAi. MSigDB C6: Oncogenic Signatures (v5.1) 4.307E-5 3.585E-3 3.077E-2
1.291E-1
 4 149
36 M8512 Genes up-regulated in TK6, WTK1, and NH32 cell lines (lymphoblast) in response to ionizing radiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.307E-5 3.585E-3 3.077E-2
1.291E-1
 4 149
37 M17287 Genes down-regulated in LNCaP cells (prostate cancer) by overexpression of SOX4 [GeneID=6659] and up-regulated by its RNAi knockdown. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.829E-5 3.911E-3 3.357E-2
1.447E-1
 5 308
38 M17730 Genes up-regulated in quescent CD34+ [GeneID=8842] cells isolated from peripheral blood of CML (chronic myeloblastic leukemia) patients compared to the dividing cells from normal donors. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.848E-5 4.585E-3 3.935E-2
1.753E-1
 3 57
39 GSE25146 UNSTIM VS HELIOBACTER PYLORI LPS STIM AGS CELL DN Genes down-regulated in AGS cells (gastric adenocarcinoma): control versus H. pylori LPS. MSigDB C7: Immunologic Signatures (v5.1) 5.966E-5 4.585E-3 3.935E-2
1.788E-1
 4 162
40 M3475 Genes up-regulated 6 h after induction of HoxA5 [GeneID=3205] expression in a breast cancer cell line. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.592E-5 5.387E-3 4.624E-2
2.275E-1
 2 10
41 M9775 Genes up-regulated in T helper cells (defines as CD4+) isolated from patients with mucosis fungoides compared to those from normal control donors. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.275E-5 5.387E-3 4.624E-2
2.480E-1
 3 64
42 M1405 Genes up-regulated in germinal center T helper cells compared to other CD4+ [GeneID=920] T lymphocyte types. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.072E-5 5.387E-3 4.624E-2
2.719E-1
 3 66
43 M1417 Genes down-regulated during epithelial to mesenchymal transition (EMT) induced by TGFB1 [GeneID=7040] in the EpH4 cells (mammary epithelium cell line transformed by HRAS [GeneID=3265]). MSigDB C2: CGP Curated Gene Sets (v5.1) 9.072E-5 5.387E-3 4.624E-2
2.719E-1
 3 66
44 GSE37605 FOXP3 FUSION GFP VS IRES GFP TREG C57BL6 UP Genes up-regulated in T reg (FOXP3+ [GeneID=50943]) cells from B6 mice: Foxp3-Fusion-GFP versus Foxp3-ires-GFP. MSigDB C7: Immunologic Signatures (v5.1) 9.371E-5 5.387E-3 4.624E-2
2.808E-1
 4 182
45 GSE7219 WT VS NIK NFKB2 KO DC UP Genes up-regulated in dendritic cells: wildtype versus NFKB2 [GeneID=4791]. MSigDB C7: Immunologic Signatures (v5.1) 9.775E-5 5.387E-3 4.624E-2
2.930E-1
 4 184
46 M15615 Genes up-regulated in HT1080 (fibrosarcoma) cells by treatment with interferon gamma for 6 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.128E-4 5.387E-3 4.624E-2
3.381E-1
 3 71
47 GSE40685 TREG VS FOXP3 KO TREG PRECURSOR UP Genes up-regulated in CD4: FOXP3+ [GeneID=50943] T reg versus FOXP3 [GeneID=50943] knockout T reg precursor. MSigDB C7: Immunologic Signatures (v5.1) 1.223E-4 5.387E-3 4.624E-2
3.665E-1
 4 195
48 M4943 Genes up-regulated in comparison of B cells versus myeloid dendritic cells (mDC). MSigDB C7: Immunologic Signatures (v5.1) 1.223E-4 5.387E-3 4.624E-2
3.665E-1
 4 195
49 M11516 Selected genes changed in K562 (immortalized erythroleukemia) cells induced by hemin [PubChem=26945] treatment to express erythroid properties. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.225E-4 5.387E-3 4.624E-2
3.672E-1
 3 73
50 M5852 Genes up-regulated in comparison of monocytes treated with anti-TREM1 [GeneID=54210] versus monocytes treated wth vehicle. MSigDB C7: Immunologic Signatures (v5.1) 1.247E-4 5.387E-3 4.624E-2
3.738E-1
 4 196
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 996 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 200 k1 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.596E-6 2.501E-3 1.871E-2 3.581E-3 3 22
2 PCBC ratio EB BM CD34+ vs EB blastocyst cfr-2X-p05 EB BM CD34+ vs EB blastocyst-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 5.021E-6 2.501E-3 1.871E-2 5.001E-3 4 83
3 gudmap dev gonad e11.5 M GonMes Sma k4 200 dev gonad e11.5 M GonMes Sma k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 9.409E-6 3.124E-3 2.337E-2 9.372E-3 3 30
4 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 500 k5 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 k-means-cluster#5 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.097E-5 5.220E-3 3.906E-2 2.088E-2 4 119
5 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 1000 k3 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.550E-5 6.407E-3 4.794E-2 3.535E-2 5 277
6 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 100 k4 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 k-means-cluster#4 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 3.860E-5 6.407E-3 4.794E-2 3.844E-2 2 7
7 PCBC ratio iPSC method-OSK-l-N-p53KD vs ESC cfr-2X-p05 Pluripotent Stem Cells-reprogram OSK-l-N-p53KD vs Pluripotent Stem Cells-reprogram NA-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 4.550E-5 6.474E-3 4.843E-2 4.532E-2 4 145
8 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 500 k4 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.314E-5 6.616E-3 4.950E-2
5.293E-2
 3 53
9 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 200 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 8.255E-5 8.020E-3
6.000E-2
8.222E-2
 4 169
10 gudmap dev gonad e11.5 M GonMes Sma k3 500 dev gonad e11.5 M GonMes Sma k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 8.508E-5 8.020E-3
6.000E-2
8.474E-2
 3 62
11 gudmap dev gonad e11.5 M GonMes Sma 200 dev gonad e11.5 M GonMes Sma top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 9.660E-5 8.020E-3
6.000E-2
9.621E-2
 4 176
12 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 100 k2 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.007E-4 8.020E-3
6.000E-2
1.003E-1
 2 11
13 gudmap dev gonad e11.5 F ReproVasc Flk k4 1000 dev gonad e11.5 F ReproVasc Flk k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.121E-4 8.020E-3
6.000E-2
1.117E-1
 3 68
14 DevelopingKidney e15.5 Endothelial cells emap-29977 k1 500 DevelopingKidney e15.5 Endothelial cells emap-29977 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.208E-4 8.020E-3
6.000E-2
1.203E-1
 2 12
15 gudmap developingKidney e15.5 Cap mesenchyme 100 k1 DevelopingKidney e15.5 Cap mesenchyme emap-27738 k-means-cluster#1 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.208E-4 8.020E-3
6.000E-2
1.203E-1
 2 12
16 gudmap developingLowerUrinaryTract e13.5 bladder mesenchyme 100 k2 DevelopingLowerUrinaryTract e13.5 bladder mesenchyme emap-3087 k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.426E-4 8.879E-3
6.643E-2
1.421E-1
 2 13
17 gudmap developingKidney e15.5 Endothelial cells 1000 k4 DevelopingKidney e15.5 Endothelial cells emap-29965 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.751E-4 1.026E-2
7.676E-2
1.744E-1
 3 79
18 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 200 k4 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.917E-4 1.038E-2
7.766E-2
1.909E-1
 2 15
19 PCBC ratio EB from-OSK-L-l-p53KD vs EB from-ESC cfr-2X-p05 Embryoid Body Cells-reprogram OSK-L-l-p53KD vs Embryoid Body Cells-reprogram NA-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 2.100E-4 1.038E-2
7.766E-2
2.092E-1
 3 84
20 gudmap developingKidney e15.5 Endothelial cells 500 k3 DevelopingKidney e15.5 Endothelial cells emap-29965 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.189E-4 1.038E-2
7.766E-2
2.180E-1
 2 16
21 gudmap developingLowerUrinaryTract e13.5 bladder mesenchyme 200 k1 DevelopingLowerUrinaryTract e13.5 bladder mesenchyme emap-3087 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.189E-4 1.038E-2
7.766E-2
2.180E-1
 2 16
22 endothelial SubClass DCN-hi Top 500 Cluster 3 endothelial SubClass DCN-hi Top 500 Cluster 3 Brain Map - Barres 2.330E-4 1.044E-2
7.807E-2
2.320E-1
 3 87
23 gudmap dev gonad e11.5 M ReproVasc Flk k2 1000 dev gonad e11.5 M ReproVasc Flk k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.410E-4 1.044E-2
7.807E-2
2.400E-1
 3 88
24 mendel RNAseq e17.5 Urothelium ShhCreRFP 2500 K1 mendel RNAseq e17.5 Urothelium ShhCreRFP 2500 K1 Gudmap RNAseq 3.178E-4 1.319E-2
9.868E-2
3.166E-1
 7 989
25 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 1000 k2 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.616E-4 1.441E-2
1.078E-1
3.601E-1
 3 101
26 DevelopingKidney e15.5 Endothelial cells emap-29977 k1 1000 DevelopingKidney e15.5 Endothelial cells emap-29977 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.940E-4 1.495E-2
1.118E-1
3.924E-1
 3 104
27 Facebase RNAseq e10.5 Medial Nasal Eminence 500 K4 FacebaseRNAseq e10.5 Medial Nasal Eminence top-relative-expression-ranked 500 k-means-cluster#4 FaceBase_RNAseq 4.052E-4 1.495E-2
1.118E-1
4.036E-1
 3 105
28 gudmap RNAseq p2 Glomerlular Endothelial 2500 K2 gudmap RNAseq p2 Glomerlular Endothelial 2500 K2 Gudmap RNAseq 4.950E-4 1.761E-2
1.317E-1
4.930E-1
 4 270
29 OPC Top 500 All OPC Top 500 All Brain Map - Barres 5.285E-4 1.815E-2
1.358E-1
5.263E-1
 5 494
30 gudmap dev gonad e12.5 F VasAssocMesStromOvary Sma k3 500 dev gonad e12.5 F VasAssocMesStromOvary Sma k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 5.561E-4 1.846E-2
1.381E-1
5.539E-1
 3 117
31 facebase RNAseq e10.5 MaxArch 2500 K4 facebase RNAseq e10.5 MaxArch 2500 K4 Gudmap RNAseq 6.433E-4 2.067E-2
1.546E-1
6.407E-1
 3 123
32 gudmap dev gonad e11.5 F ReproVasc Flk k1 500 dev gonad e11.5 F ReproVasc Flk k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 7.323E-4 2.279E-2
1.705E-1
7.294E-1
 2 29
33 gudmap dev gonad e11.5 F GonMes Sma k4 200 dev gonad e11.5 F GonMes Sma k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 7.839E-4 2.366E-2
1.770E-1
7.808E-1
 2 30
34 gudmap developingKidney e15.5 Cap mesenchyme 200 k4 DevelopingKidney e15.5 Cap mesenchyme emap-27738 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 8.373E-4 2.453E-2
1.835E-1
8.339E-1
 2 31
35 GSM605756 500 alpha beta T cells, T.4.Pa.BDC, 4+ 8- BDC+, Pancreas, avg-2 Immgen.org, GSE15907 1.024E-3 2.914E-2
2.180E-1
1.000E0
 4 328
36 gudmap dev gonad e11.5 F GonMes Sma k3 500 dev gonad e11.5 F GonMes Sma k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.121E-3 3.018E-2
2.258E-1
1.000E0
 3 149
37 gudmap dev gonad e11.5 F GonadVasMes Flk k4 500 dev gonad e11.5 F GonadVasMes Flk k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.121E-3 3.018E-2
2.258E-1
1.000E0
 3 149
38 gudmap developingKidney e15.5 Cap mesenchyme 200 DevelopingKidney e15.5 Cap mesenchyme emap-27738 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.376E-3 3.607E-2
2.698E-1
1.000E0
 3 160
39 gudmap RNAseq e15.5 Mesangium 2500 K4 gudmap RNAseq e15.5 Mesangium 2500 K4 Gudmap RNAseq 1.451E-3 3.707E-2
2.773E-1
1.000E0
 3 163
40 Lungmap Mouse e18.5 Epithelial (GSE52583) SubClass Clara Top 500 Cluster 4 Mouse Lung E18.5 Epithelial Clara c4 Lungmap Mouse Single Cell (Lungmap.net) 1.583E-3 3.941E-2
2.948E-1
1.000E0
 3 168
41 gudmap dev gonad e11.5 F GonMes Sma 200 dev gonad e11.5 F GonMes Sma top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 2.020E-3 4.908E-2
3.672E-1
1.000E0
 3 183
42 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 500 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.161E-3 4.936E-2
3.693E-1
1.000E0
 4 402
43 gudmap developingLowerUrinaryTract e13.5 bladder mesenchyme 500 k5 DevelopingLowerUrinaryTract e13.5 bladder mesenchyme emap-3087 k-means-cluster#5 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.170E-3 4.936E-2
3.693E-1
1.000E0
 2 50
44 mendel RNAseq e12.5 Urothelium ShhCreRFP 2500 K1 mendel RNAseq e12.5 Urothelium ShhCreRFP 2500 K1 Gudmap RNAseq 2.180E-3 4.936E-2
3.693E-1
1.000E0
 4 403
Show 39 more annotations

15: Computational [Display Chart] 184 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 123 Genes in module 123 MSigDb: C4 - CM: Cancer Modules 8.360E-11 1.538E-8 8.914E-8 1.538E-8 10 240
2 module 98 Genes in module 98 MSigDb: C4 - CM: Cancer Modules 7.603E-9 6.995E-7 4.053E-6 1.399E-6 10 381
3 module 197 Genes in module 197 MSigDb: C4 - CM: Cancer Modules 2.507E-6 1.538E-4 8.910E-4 4.613E-4 6 170
4 module 252 Genes in module 252 MSigDb: C4 - CM: Cancer Modules 1.329E-5 6.113E-4 3.543E-3 2.445E-3 6 227
5 module 198 Genes in module 198 MSigDb: C4 - CM: Cancer Modules 5.516E-5 2.030E-3 1.176E-2 1.015E-2 6 292
6 MORF RFC5 Neighborhood of RFC5 MSigDb: C4 - CGN: Cancer Gene Neighborhood 6.564E-4 2.013E-2
1.166E-1
1.208E-1
 3 71
7 module 1 Genes in module 1 MSigDb: C4 - CM: Cancer Modules 1.544E-3 4.057E-2
2.351E-1
2.840E-1
 5 361
Show 2 more annotations

16: MicroRNA [Display Chart] 1354 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-548m:PITA hsa-miR-548m:PITA TOP PITA 3.302E-6 4.471E-3 3.482E-2 4.471E-3 7 457
2 hsa-miR-125b:miRTarbase hsa-miR-125b:miRTarbase miRTarbase 3.821E-5 2.399E-2
1.868E-1
5.173E-2
 3 45
3 hsa-miR-384:PITA hsa-miR-384:PITA TOP PITA 7.488E-5 2.399E-2
1.868E-1
1.014E-1
 4 156
4 hsa-miR-34a:miRTarbase hsa-miR-34a:miRTarbase miRTarbase 1.001E-4 2.399E-2
1.868E-1
1.356E-1
 3 62
5 hsa-miR-200c:PITA hsa-miR-200c:PITA TOP PITA 1.357E-4 2.399E-2
1.868E-1
1.838E-1
 7 815
6 hsa-miR-200b:PITA hsa-miR-200b:PITA TOP PITA 1.357E-4 2.399E-2
1.868E-1
1.838E-1
 7 815
7 hsa-miR-429:PITA hsa-miR-429:PITA TOP PITA 1.389E-4 2.399E-2
1.868E-1
1.880E-1
 7 818
8 TGTGTGA,MIR-377:MSigDB TGTGTGA,MIR-377:MSigDB MSigDB 1.417E-4 2.399E-2
1.868E-1
1.919E-1
 4 184
9 hsa-miR-4259:mirSVR highEffct hsa-miR-4259:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.008E-4 2.545E-2
1.982E-1
2.719E-1
 6 603
10 miR-124a:PicTar miR-124a:PicTar PicTar 2.459E-4 2.545E-2
1.982E-1
3.329E-1
 6 626
11 hsa-miR-338-3p:PITA hsa-miR-338-3p:PITA TOP PITA 2.665E-4 2.545E-2
1.982E-1
3.609E-1
 4 217
12 GGCAGCT,MIR-22:MSigDB GGCAGCT,MIR-22:MSigDB MSigDB 2.713E-4 2.545E-2
1.982E-1
3.673E-1
 4 218
13 hsa-miR-520d-5p:PITA hsa-miR-520d-5p:PITA TOP PITA 2.770E-4 2.545E-2
1.982E-1
3.751E-1
 7 915
14 hsa-miR-524-5p:PITA hsa-miR-524-5p:PITA TOP PITA 2.770E-4 2.545E-2
1.982E-1
3.751E-1
 7 915
15 CTTTGTA,MIR-524:MSigDB CTTTGTA,MIR-524:MSigDB MSigDB 2.866E-4 2.545E-2
1.982E-1
3.880E-1
 5 409
16 miR-139:PicTar miR-139:PicTar PicTar 3.008E-4 2.545E-2
1.982E-1
4.073E-1
 4 224
17 miR-199a-star:PicTar miR-199a-star:PicTar PicTar 3.310E-4 2.636E-2
2.053E-1
4.481E-1
 5 422
18 miR-144:PicTar miR-144:PicTar PicTar 3.725E-4 2.802E-2
2.182E-1
5.043E-1
 5 433
19 miR-22:PicTar miR-22:PicTar PicTar 6.174E-4 4.360E-2
3.395E-1
8.360E-1
 4 271
20 hsa-miR-610:PITA hsa-miR-610:PITA TOP PITA 7.025E-4 4.360E-2
3.395E-1
9.512E-1
 3 120
21 ACTGTAG,MIR-139:MSigDB ACTGTAG,MIR-139:MSigDB MSigDB 7.025E-4 4.360E-2
3.395E-1
9.512E-1
 3 120
22 hsa-miR-338-5p:PITA hsa-miR-338-5p:PITA TOP PITA 7.549E-4 4.360E-2
3.395E-1
1.000E0
 6 773
23 hsa-miR-511:PITA hsa-miR-511:PITA TOP PITA 7.699E-4 4.360E-2
3.395E-1
1.000E0
 5 508
24 ACACTAC,MIR-142-3P:MSigDB ACACTAC,MIR-142-3P:MSigDB MSigDB 7.728E-4 4.360E-2
3.395E-1
1.000E0
 3 124
25 TGCCTTA,MIR-124A:MSigDB TGCCTTA,MIR-124A:MSigDB MSigDB 8.117E-4 4.386E-2
3.416E-1
1.000E0
 5 514
26 hsa-miR-524-3p:PITA hsa-miR-524-3p:PITA TOP PITA 8.745E-4 4.386E-2
3.416E-1
1.000E0
 2 30
27 hsa-miR-525-3p:PITA hsa-miR-525-3p:PITA TOP PITA 8.745E-4 4.386E-2
3.416E-1
1.000E0
 2 30
28 miR-142-5p:PicTar miR-142-5p:PicTar PicTar 9.951E-4 4.812E-2
3.748E-1
1.000E0
 4 308
29 hsa-miR-582-5p:PITA hsa-miR-582-5p:PITA TOP PITA 1.047E-3 4.887E-2
3.806E-1
1.000E0
 5 544
30 hsa-miR-1298:PITA hsa-miR-1298:PITA TOP PITA 1.124E-3 4.950E-2
3.855E-1
1.000E0
 2 34
31 hsa-miR-139-5p:PITA hsa-miR-139-5p:PITA TOP PITA 1.133E-3 4.950E-2
3.855E-1
1.000E0
 4 319
Show 26 more annotations

17: Drug [Display Chart] 10804 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000444218 AC1L9FY1 Stitch 4.848E-11 3.321E-7 3.276E-6 5.238E-7 7 101
2 5202 DN ICI 182,780; Down 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP 6.148E-11 3.321E-7 3.276E-6 6.643E-7 8 180
3 CID000099040 Sp 1 (pharmaceutical) Stitch 1.063E-9 2.586E-6 2.551E-5 1.148E-5 10 548
4 486 UP calmidazolium chloride; Up 200; 5uM; MCF7; HG-U133A Broad Institute CMAP 1.548E-9 2.586E-6 2.551E-5 1.672E-5 7 165
5 4801 UP Digitoxigenin [143-62-4]; Up 200; 10.6uM; MCF7; HT HG-U133A Broad Institute CMAP 1.684E-9 2.586E-6 2.551E-5 1.819E-5 7 167
6 5310 UP Puromycin dihydrochloride [58-58-2]; Up 200; 7.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.755E-9 2.586E-6 2.551E-5 1.896E-5 7 168
7 CID000005562 A25618 Stitch 1.836E-9 2.586E-6 2.551E-5 1.984E-5 11 777
8 5026 UP Strophantine octahydrate [11018-89-6]; Up 200; 5.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.986E-9 2.586E-6 2.551E-5 2.146E-5 7 171
9 949 UP 5255229; Up 200; 13uM; MCF7; HT HG-U133A EA Broad Institute CMAP 2.154E-9 2.586E-6 2.551E-5 2.327E-5 7 173
10 3144 DN Deptropine citrate [2169-75-7]; Down 200; 7.6uM; HL60; HT HG-U133A Broad Institute CMAP 4.136E-9 4.468E-6 4.408E-5 4.468E-5 7 190
11 CID000499953 phorbol-13-acetate Stitch 6.749E-9 6.629E-6 6.539E-5 7.292E-5 8 326
12 CID000003154 Cosopt Stitch 9.586E-9 8.631E-6 8.514E-5 1.036E-4 8 341
13 CID000114777 theaflavin Stitch 1.293E-8 1.003E-5 9.899E-5 1.397E-4 7 224
14 CID000013588 cyclopentenone Stitch 1.300E-8 1.003E-5 9.899E-5 1.405E-4 6 126
15 D004137 Dinitrochlorobenzene CTD 1.526E-8 1.099E-5 1.084E-4 1.649E-4 8 362
16 C568608 PCI 5002 CTD 1.761E-8 1.189E-5 1.173E-4 1.903E-4 10 735
17 D008769 Methylnitronitrosoguanidine CTD 3.897E-8 2.220E-5 2.190E-4 4.211E-4 7 263
18 6823 UP Terfenadine [50679-08-8]; Up 200; 8.4uM; MCF7; HT HG-U133A Broad Institute CMAP 3.998E-8 2.220E-5 2.190E-4 4.320E-4 6 152
19 CID003918406 pyro-Glu-His-Gly Stitch 4.053E-8 2.220E-5 2.190E-4 4.379E-4 3 6
20 MESH:D008175/D005557-M Lung Neoplasms affected by Formaldehyde CTD Marker 4.110E-8 2.220E-5 2.190E-4 4.440E-4 4 27
21 5275 UP Digoxigenin [1672-46-4]; Up 200; 10.2uM; MCF7; HT HG-U133A Broad Institute CMAP 5.428E-8 2.792E-5 2.755E-4 5.864E-4 6 160
22 7188 UP Fendiline hydrochloride [13636-18-5]; Up 200; 11.4uM; MCF7; HT HG-U133A Broad Institute CMAP 6.287E-8 2.953E-5 2.913E-4 6.792E-4 6 164
23 3963 UP Lanatoside C [17575-22-3]; Up 200; 4uM; MCF7; HT HG-U133A Broad Institute CMAP 6.287E-8 2.953E-5 2.913E-4 6.792E-4 6 164
24 5324 UP Digoxin [20830-75-5]; Up 200; 5.2uM; MCF7; HT HG-U133A Broad Institute CMAP 6.756E-8 3.042E-5 3.000E-4 7.300E-4 6 166
25 965 UP felodipine; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 7.783E-8 3.364E-5 3.318E-4 8.409E-4 6 170
26 2456 UP Ciclopirox ethanolamine [41621-49-2]; Up 200; 15uM; HL60; HT HG-U133A Broad Institute CMAP 8.935E-8 3.713E-5 3.663E-4 9.653E-4 6 174
27 CID006540269 2BrP Stitch 1.298E-7 5.195E-5 5.125E-4 1.403E-3 5 93
28 D017638 Asbestos, Crocidolite CTD 1.388E-7 5.251E-5 5.180E-4 1.499E-3 9 682
29 5203 DN 17-AAG; Down 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.458E-7 5.251E-5 5.180E-4 1.575E-3 6 189
30 5578 DN 17-AAG; Down 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.458E-7 5.251E-5 5.180E-4 1.575E-3 6 189
31 4961 DN Tocopherol (R,S) [10191-41-0]; Down 200; 9.2uM; MCF7; HT HG-U133A Broad Institute CMAP 1.754E-7 5.743E-5 5.666E-4 1.895E-3 6 195
32 4646 DN Meclozine dihydrochloride [1104-22-9]; Down 200; 8.6uM; PC3; HT HG-U133A Broad Institute CMAP 1.754E-7 5.743E-5 5.666E-4 1.895E-3 6 195
33 7346 DN 6-Hydroxytropinone [5932-53-6]; Down 200; 25.8uM; MCF7; HT HG-U133A Broad Institute CMAP 1.807E-7 5.743E-5 5.666E-4 1.953E-3 6 196
34 2374 DN Diphenidol hydrochloride [3254-89-5]; Down 200; 11.6uM; HL60; HT HG-U133A Broad Institute CMAP 1.807E-7 5.743E-5 5.666E-4 1.953E-3 6 196
35 6256 DN Bupropion hydrochloride [31677-93-7]; Down 200; 14.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.977E-7 6.102E-5 6.020E-4 2.136E-3 6 199
36 MESH:D008175/D003474-T Lung Neoplasms affected by Curcumin CTD Therapeutic 2.342E-7 6.838E-5 6.745E-4 2.530E-3 4 41
37 MESH:D008175/D003474-M Lung Neoplasms affected by Curcumin CTD Marker 2.342E-7 6.838E-5 6.745E-4 2.530E-3 4 41
38 MESH:D008175/D024502-T Lung Neoplasms affected by alpha-Tocopherol CTD Therapeutic 2.423E-7 6.890E-5 6.797E-4 2.618E-3 3 10
39 CID000002019 Actinomycin D Stitch 2.661E-7 7.373E-5 7.273E-4 2.875E-3 8 525
40 CID000176155 SB203580 Stitch 3.953E-7 1.054E-4 1.039E-3 4.270E-3 9 772
41 C081489 valsartan CTD 4.096E-7 1.054E-4 1.039E-3 4.425E-3 5 117
42 D000068756 Valsartan CTD 4.096E-7 1.054E-4 1.039E-3 4.425E-3 5 117
43 CID000005040 NSC226080 Stitch 4.451E-7 1.093E-4 1.078E-3 4.809E-3 9 783
44 C027576 4-hydroxy-2-nonenal CTD 4.451E-7 1.093E-4 1.078E-3 4.809E-3 9 783
45 CID004369394 AR E Stitch 4.631E-7 1.112E-4 1.097E-3 5.003E-3 6 230
46 CID000442783 AC1L9DEH Stitch 4.899E-7 1.151E-4 1.135E-3 5.293E-3 8 569
47 D003474 Curcumin CTD 5.557E-7 1.277E-4 1.260E-3 6.003E-3 9 804
48 CID000006569 methyl ethyl ketone Stitch 6.198E-7 1.395E-4 1.376E-3 6.697E-3 8 587
49 CID006436256 AC1O5LBK Stitch 6.388E-7 1.409E-4 1.390E-3 6.902E-3 6 243
50 CID000467320 AC1LAF7F Stitch 6.698E-7 1.447E-4 1.428E-3 7.236E-3 4 53
Show 45 more annotations

18: Disease [Display Chart] 920 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0023470 Myeloid Leukemia DisGeNET Curated 2.232E-8 2.054E-5 1.520E-4 2.054E-5 9 458
2 umls:C0023493 Adult T-Cell Lymphoma/Leukemia DisGeNET Curated 4.123E-7 1.467E-4 1.086E-3 3.793E-4 8 461
3 umls:C2931822 Nasopharyngeal carcinoma DisGeNET Curated 4.785E-7 1.467E-4 1.086E-3 4.402E-4 9 656
4 umls:C0206180 Ki-1+ Anaplastic Large Cell Lymphoma DisGeNET Curated 2.355E-6 5.416E-4 4.009E-3 2.166E-3 6 251
5 umls:C0011644 Scleroderma DisGeNET BeFree 5.966E-6 1.098E-3 8.126E-3 5.489E-3 5 166
6 umls:C0034067 Pulmonary Emphysema DisGeNET Curated 7.505E-6 1.151E-3 8.518E-3 6.904E-3 5 174
7 umls:C0598935 Tumor Initiation DisGeNET BeFree 9.338E-6 1.227E-3 9.085E-3 8.591E-3 5 182
8 umls:C0002793 Anaplasia DisGeNET Curated 2.951E-5 3.393E-3 2.512E-2 2.715E-2 5 231
9 umls:C0153014 Non-arthropod borne lymphocytic choriomeningitis DisGeNET BeFree 4.696E-5 4.800E-3 3.553E-2 4.320E-2 3 44
10 umls:C0024266 Lymphocytic Choriomeningitis DisGeNET BeFree 9.193E-5 7.076E-3
5.237E-2
8.457E-2
 3 55
11 umls:C0003850 Arteriosclerosis DisGeNET Curated 1.015E-4 7.076E-3
5.237E-2
9.340E-2
 8 976
12 umls:C0151650 Renal fibrosis DisGeNET BeFree 1.088E-4 7.076E-3
5.237E-2
1.001E-1
 4 157
13 umls:C0004153 Atherosclerosis DisGeNET Curated 1.146E-4 7.076E-3
5.237E-2
1.054E-1
 8 993
14 umls:C0281361 Adenocarcinoma of pancreas DisGeNET BeFree 1.174E-4 7.076E-3
5.237E-2
1.080E-1
 5 309
15 umls:C0079744 Diffuse Large B-Cell Lymphoma DisGeNET Curated 1.225E-4 7.076E-3
5.237E-2
1.127E-1
 6 505
16 umls:C1261473 Sarcoma DisGeNET Curated 1.231E-4 7.076E-3
5.237E-2
1.132E-1
 7 737
17 umls:C0040100 Thymoma DisGeNET Curated 1.318E-4 7.132E-3
5.279E-2
1.212E-1
 4 165
18 umls:C0024301 Lymphoma, Follicular DisGeNET Curated 1.552E-4 7.400E-3
5.478E-2
1.428E-1
 5 328
19 umls:C0036421 Systemic Scleroderma DisGeNET Curated 1.613E-4 7.400E-3
5.478E-2
1.484E-1
 6 531
20 umls:C0024121 Lung Neoplasms DisGeNET Curated 1.656E-4 7.400E-3
5.478E-2
1.524E-1
 7 773
21 umls:C0023492 Leukemia, T-Cell DisGeNET Curated 1.689E-4 7.400E-3
5.478E-2
1.554E-1
 5 334
22 umls:C0152013 Adenocarcinoma of lung (disorder) DisGeNET Curated 2.096E-4 8.767E-3
6.489E-2
1.929E-1
 7 803
23 umls:C1961099 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma DisGeNET Curated 2.333E-4 9.331E-3
6.907E-2
2.146E-1
 5 358
24 umls:C0035126 Reperfusion Injury DisGeNET Curated 3.352E-4 1.235E-2
9.143E-2
3.084E-1
 3 85
25 umls:C0334299 Carcinoid tumor no ICD-O subtype DisGeNET BeFree 3.589E-4 1.235E-2
9.143E-2
3.302E-1
 3 87
26 umls:C0553580 Ewings sarcoma DisGeNET Curated 3.628E-4 1.235E-2
9.143E-2
3.338E-1
 4 215
27 umls:C0020456 Hyperglycemia DisGeNET Curated 3.891E-4 1.235E-2
9.143E-2
3.580E-1
 5 400
28 umls:C0007847 Malignant tumor of cervix DisGeNET BeFree 3.910E-4 1.235E-2
9.143E-2
3.597E-1
 7 889
29 umls:C2004493 Leukemia, B-Cell DisGeNET BeFree 4.230E-4 1.235E-2
9.143E-2
3.892E-1
 3 92
30 umls:C0549473 Thyroid carcinoma DisGeNET Curated 4.235E-4 1.235E-2
9.143E-2
3.896E-1
 6 635
31 umls:C0040128 Thyroid Diseases DisGeNET Curated 4.366E-4 1.235E-2
9.143E-2
4.017E-1
 3 93
32 umls:C0555198 Malignant Glioma DisGeNET BeFree 4.456E-4 1.235E-2
9.143E-2
4.099E-1
 5 412
33 umls:C0022680 Polycystic Kidney Diseases DisGeNET Curated 4.505E-4 1.235E-2
9.143E-2
4.145E-1
 3 94
34 umls:C0004114 Astrocytoma DisGeNET Curated 4.565E-4 1.235E-2
9.143E-2
4.200E-1
 6 644
35 umls:C0270972 Cornelia De Lange Syndrome DisGeNET Curated 5.644E-4 1.484E-2
1.098E-1
5.193E-1
 2 22
36 umls:C0079740 High Grade Lymphoma (neoplasm) DisGeNET BeFree 6.176E-4 1.536E-2
1.137E-1
5.682E-1
 2 23
37 umls:C1322286 Thymoma, type C DisGeNET BeFree 6.176E-4 1.536E-2
1.137E-1
5.682E-1
 2 23
38 umls:C3539878 Triple Negative Breast Neoplasms DisGeNET BeFree 7.069E-4 1.683E-2
1.246E-1
6.504E-1
 5 456
39 umls:C0036472 Scrub Typhus DisGeNET BeFree 7.308E-4 1.683E-2
1.246E-1
6.724E-1
 2 25
40 umls:C0079772 T-Cell Lymphoma DisGeNET Curated 7.317E-4 1.683E-2
1.246E-1
6.732E-1
 4 259
41 umls:C1279296 Chronic leukemia (category) DisGeNET BeFree 7.910E-4 1.740E-2
1.288E-1
7.277E-1
 2 26
42 umls:C0079774 Peripheral T-Cell Lymphoma DisGeNET Curated 8.532E-4 1.740E-2
1.288E-1
7.849E-1
 3 117
43 umls:C0085702 Monocytosis DisGeNET BeFree 8.534E-4 1.740E-2
1.288E-1
7.851E-1
 2 27
44 umls:C0085669 Acute leukemia DisGeNET BeFree 8.743E-4 1.740E-2
1.288E-1
8.044E-1
 5 478
45 umls:C0205969 Thymic Carcinoma DisGeNET BeFree 1.054E-3 1.740E-2
1.288E-1
9.701E-1
 2 30
46 umls:C0242656 Disease Progression DisGeNET Curated 1.082E-3 1.740E-2
1.288E-1
9.952E-1
 3 127
47 umls:C0042341 Varicocele DisGeNET BeFree 1.126E-3 1.740E-2
1.288E-1
1.000E0
 2 31
48 umls:C0014335 Enteritis DisGeNET Curated 1.126E-3 1.740E-2
1.288E-1
1.000E0
 2 31
49 umls:C0009375 Colonic Neoplasms DisGeNET Curated 1.148E-3 1.740E-2
1.288E-1
1.000E0
 5 508
50 umls:C0035235 Respiratory Syncytial Virus Infections DisGeNET Curated 1.183E-3 1.740E-2
1.288E-1
1.000E0
 3 131
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