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1: GO: Molecular Function [Display Chart] 211 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:1990837 sequence-specific double-stranded DNA binding 4.851E-18 1.024E-15 6.071E-15 1.024E-15 16 736
2 GO:0003690 double-stranded DNA binding 2.913E-17 2.802E-15 1.662E-14 6.147E-15 16 824
3 GO:0044212 transcription regulatory region DNA binding 5.949E-17 2.802E-15 1.662E-14 1.255E-14 16 862
4 GO:0000975 regulatory region DNA binding 6.286E-17 2.802E-15 1.662E-14 1.326E-14 16 865
5 GO:0001067 regulatory region nucleic acid binding 6.639E-17 2.802E-15 1.662E-14 1.401E-14 16 868
6 GO:0000976 transcription regulatory region sequence-specific DNA binding 1.288E-16 4.531E-15 2.688E-14 2.719E-14 15 705
7 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding 4.281E-15 1.290E-13 7.654E-13 9.032E-13 12 380
8 GO:0000987 core promoter proximal region sequence-specific DNA binding 7.672E-15 1.909E-13 1.133E-12 1.619E-12 12 399
9 GO:0001159 core promoter proximal region DNA binding 8.145E-15 1.909E-13 1.133E-12 1.718E-12 12 401
10 GO:0008134 transcription factor binding 7.206E-13 1.521E-11 9.019E-11 1.521E-10 12 585
11 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding 1.790E-12 3.433E-11 2.036E-10 3.777E-10 12 632
12 GO:0001012 RNA polymerase II regulatory region DNA binding 2.000E-12 3.517E-11 2.086E-10 4.220E-10 12 638
13 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding 4.083E-12 6.627E-11 3.931E-10 8.615E-10 12 678
14 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding 1.907E-10 2.875E-9 1.705E-8 4.024E-8 9 358
15 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding 2.264E-10 3.185E-9 1.889E-8 4.777E-8 9 365
16 GO:0003682 chromatin binding 4.743E-9 6.255E-8 3.710E-7 1.001E-6 9 516
17 GO:0000989 transcription factor activity, transcription factor binding 2.085E-8 2.586E-7 1.534E-6 4.400E-6 9 612
18 GO:0000988 transcription factor activity, protein binding 2.206E-8 2.586E-7 1.534E-6 4.655E-6 9 616
19 GO:0003712 transcription cofactor activity 2.097E-7 2.329E-6 1.381E-5 4.425E-5 8 566
20 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding 2.303E-7 2.417E-6 1.434E-5 4.860E-5 5 114
21 GO:0001046 core promoter sequence-specific DNA binding 2.406E-7 2.417E-6 1.434E-5 5.077E-5 5 115
22 GO:0001047 core promoter binding 1.444E-6 1.385E-5 8.214E-5 3.047E-4 5 165
23 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding 2.339E-6 2.146E-5 1.273E-4 4.936E-4 5 182
24 GO:0031490 chromatin DNA binding 3.214E-6 2.826E-5 1.676E-4 6.782E-4 4 85
25 GO:0043425 bHLH transcription factor binding 6.336E-6 5.348E-5 3.172E-4 1.337E-3 3 30
26 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding 8.048E-6 6.531E-5 3.874E-4 1.698E-3 4 107
27 GO:0001085 RNA polymerase II transcription factor binding 1.186E-5 9.269E-5 5.498E-4 2.503E-3 4 118
28 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding 1.305E-5 9.834E-5 5.833E-4 2.754E-3 5 259
29 GO:0043566 structure-specific DNA binding 1.537E-5 1.118E-4 6.634E-4 3.243E-3 4 126
30 GO:0004407 histone deacetylase activity 1.775E-5 1.248E-4 7.403E-4 3.744E-3 3 42
31 GO:0033558 protein deacetylase activity 1.906E-5 1.297E-4 7.695E-4 4.022E-3 3 43
32 GO:0035257 nuclear hormone receptor binding 4.025E-5 2.654E-4 1.574E-3 8.493E-3 4 161
33 GO:0019213 deacetylase activity 6.037E-5 3.860E-4 2.289E-3 1.274E-2 3 63
34 GO:0051427 hormone receptor binding 6.772E-5 4.183E-4 2.481E-3 1.429E-2 4 184
35 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 6.939E-5 4.183E-4 2.481E-3 1.464E-2 3 66
36 GO:0046332 SMAD binding 1.100E-4 6.281E-4 3.726E-3 2.320E-2 3 77
37 GO:0070403 NAD+ binding 1.105E-4 6.281E-4 3.726E-3 2.332E-2 2 13
38 GO:0035258 steroid hormone receptor binding 1.691E-4 6.281E-4 3.726E-3 3.568E-2 3 89
39 GO:0008418 protein-N-terminal asparagine amidohydrolase activity 1.697E-4 6.281E-4 3.726E-3 3.580E-2 2 16
40 GO:0043748 O-succinylbenzoate synthase activity 1.697E-4 6.281E-4 3.726E-3 3.580E-2 2 16
41 GO:0034876 isonicotinic acid hydrazide hydrolase activity 1.697E-4 6.281E-4 3.726E-3 3.580E-2 2 16
42 GO:0008759 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity 1.697E-4 6.281E-4 3.726E-3 3.580E-2 2 16
43 GO:0018748 iprodione amidohydrolase activity 1.697E-4 6.281E-4 3.726E-3 3.580E-2 2 16
44 GO:0043909 N-acetylcitrulline deacetylase activity 1.697E-4 6.281E-4 3.726E-3 3.580E-2 2 16
45 GO:0018749 (3,5-dichlorophenylurea)acetate amidohydrolase activity 1.697E-4 6.281E-4 3.726E-3 3.580E-2 2 16
46 GO:0034573 didemethylisoproturon amidohydrolase activity 1.697E-4 6.281E-4 3.726E-3 3.580E-2 2 16
47 GO:0034571 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity 1.697E-4 6.281E-4 3.726E-3 3.580E-2 2 16
48 GO:0034576 N-isopropylacetanilide amidohydrolase activity 1.697E-4 6.281E-4 3.726E-3 3.580E-2 2 16
49 GO:0052773 diacetylchitobiose deacetylase activity 1.697E-4 6.281E-4 3.726E-3 3.580E-2 2 16
50 GO:0043747 N2-acetyl-L-lysine deacetylase activity 1.697E-4 6.281E-4 3.726E-3 3.580E-2 2 16
Show 45 more annotations

2: GO: Biological Process [Display Chart] 2184 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000122 negative regulation of transcription from RNA polymerase II promoter 3.327E-11 7.266E-8 6.006E-7 7.266E-8 12 810
2 GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter 4.021E-9 3.564E-6 2.946E-5 8.781E-6 4 17
3 GO:0031668 cellular response to extracellular stimulus 4.896E-9 3.564E-6 2.946E-5 1.069E-5 7 215
4 GO:2000756 regulation of peptidyl-lysine acetylation 1.159E-8 6.125E-6 5.063E-5 2.531E-5 5 63
5 GO:1902893 regulation of pri-miRNA transcription from RNA polymerase II promoter 1.489E-8 6.125E-6 5.063E-5 3.251E-5 4 23
6 GO:1901983 regulation of protein acetylation 1.844E-8 6.125E-6 5.063E-5 4.028E-5 5 69
7 GO:0061614 pri-miRNA transcription from RNA polymerase II promoter 2.123E-8 6.125E-6 5.063E-5 4.637E-5 4 25
8 GO:0040029 regulation of gene expression, epigenetic 2.244E-8 6.125E-6 5.063E-5 4.900E-5 7 268
9 GO:0071496 cellular response to external stimulus 4.139E-8 9.221E-6 7.622E-5 9.039E-5 7 293
10 GO:0061061 muscle structure development 4.222E-8 9.221E-6 7.622E-5 9.221E-5 9 663
11 GO:0031669 cellular response to nutrient levels 6.488E-8 1.288E-5 1.065E-4 1.417E-4 6 181
12 GO:0071407 cellular response to organic cyclic compound 2.014E-7 3.665E-5 3.030E-4 4.398E-4 8 562
13 GO:0014706 striated muscle tissue development 3.499E-7 5.878E-5 4.859E-4 7.641E-4 7 401
14 GO:0007517 muscle organ development 4.064E-7 6.339E-5 5.240E-4 8.875E-4 7 410
15 GO:0060537 muscle tissue development 4.704E-7 6.849E-5 5.661E-4 1.027E-3 7 419
16 GO:0014857 regulation of skeletal muscle cell proliferation 5.785E-7 7.656E-5 6.329E-4 1.263E-3 3 14
17 GO:0048534 hematopoietic or lymphoid organ development 5.959E-7 7.656E-5 6.329E-4 1.302E-3 9 905
18 GO:0035065 regulation of histone acetylation 6.460E-7 7.839E-5 6.480E-4 1.411E-3 4 57
19 GO:0014856 skeletal muscle cell proliferation 8.886E-7 1.021E-4 8.443E-4 1.941E-3 3 16
20 GO:0002520 immune system development 9.440E-7 1.031E-4 8.521E-4 2.062E-3 9 956
21 GO:0045597 positive regulation of cell differentiation 1.075E-6 1.118E-4 9.244E-4 2.348E-3 9 971
22 GO:1901698 response to nitrogen compound 1.181E-6 1.173E-4 9.695E-4 2.580E-3 9 982
23 GO:0007568 aging 1.533E-6 1.456E-4 1.204E-3 3.349E-3 6 310
24 GO:0018394 peptidyl-lysine acetylation 1.788E-6 1.627E-4 1.345E-3 3.904E-3 5 172
25 GO:0002521 leukocyte differentiation 2.410E-6 2.105E-4 1.740E-3 5.263E-3 7 535
26 GO:0050767 regulation of neurogenesis 2.588E-6 2.174E-4 1.797E-3 5.653E-3 8 788
27 GO:0033002 muscle cell proliferation 2.767E-6 2.238E-4 1.850E-3 6.043E-3 5 188
28 GO:0006473 protein acetylation 3.479E-6 2.714E-4 2.243E-3 7.599E-3 5 197
29 GO:0030097 hemopoiesis 4.872E-6 3.669E-4 3.033E-3 1.064E-2 8 858
30 GO:0030099 myeloid cell differentiation 5.683E-6 4.137E-4 3.420E-3 1.241E-2 6 389
31 GO:0051960 regulation of nervous system development 6.177E-6 4.227E-4 3.494E-3 1.349E-2 8 886
32 GO:0006476 protein deacetylation 6.194E-6 4.227E-4 3.494E-3 1.353E-2 4 100
33 GO:0009991 response to extracellular stimulus 6.791E-6 4.495E-4 3.715E-3 1.483E-2 7 626
34 GO:0043543 protein acylation 7.249E-6 4.657E-4 3.849E-3 1.583E-2 5 229
35 GO:0035601 protein deacylation 7.520E-6 4.692E-4 3.879E-3 1.642E-2 4 105
36 GO:0098732 macromolecule deacylation 7.808E-6 4.737E-4 3.916E-3 1.705E-2 4 106
37 GO:0014735 regulation of muscle atrophy 8.591E-6 4.938E-4 4.082E-3 1.876E-2 2 4
38 GO:0046016 positive regulation of transcription by glucose 8.591E-6 4.938E-4 4.082E-3 1.876E-2 2 4
39 GO:0018205 peptidyl-lysine modification 1.008E-5 5.643E-4 4.665E-3 2.201E-2 6 430
40 GO:0032870 cellular response to hormone stimulus 1.155E-5 6.307E-4 5.213E-3 2.523E-2 7 679
41 GO:0016570 histone modification 1.355E-5 6.793E-4 5.616E-3 2.960E-2 6 453
42 GO:0060284 regulation of cell development 1.385E-5 6.793E-4 5.616E-3 3.024E-2 8 989
43 GO:0010942 positive regulation of cell death 1.395E-5 6.793E-4 5.616E-3 3.047E-2 7 699
44 GO:0072593 reactive oxygen species metabolic process 1.418E-5 6.793E-4 5.616E-3 3.096E-2 5 263
45 GO:0045991 carbon catabolite activation of transcription 1.431E-5 6.793E-4 5.616E-3 3.125E-2 2 5
46 GO:0014858 positive regulation of skeletal muscle cell proliferation 1.431E-5 6.793E-4 5.616E-3 3.125E-2 2 5
47 GO:0016569 covalent chromatin modification 1.630E-5 7.400E-4 6.117E-3 3.560E-2 6 468
48 GO:0051592 response to calcium ion 1.647E-5 7.400E-4 6.117E-3 3.597E-2 4 128
49 GO:0008285 negative regulation of cell proliferation 1.660E-5 7.400E-4 6.117E-3 3.626E-2 7 718
50 GO:0090241 negative regulation of histone H4 acetylation 2.145E-5 8.730E-4 7.217E-3 4.684E-2 2 6
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 117 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000785 chromatin 2.525E-9 2.954E-7 1.579E-6 2.954E-7 9 489
2 GO:0044427 chromosomal part 1.701E-8 9.952E-7 5.318E-6 1.990E-6 10 841
3 GO:0005694 chromosome 5.036E-8 1.964E-6 1.049E-5 5.892E-6 10 943
4 GO:0000790 nuclear chromatin 7.478E-8 2.187E-6 1.169E-5 8.750E-6 7 326
5 GO:0044454 nuclear chromosome part 2.054E-6 4.807E-5 2.569E-4 2.404E-4 7 533
6 GO:0000228 nuclear chromosome 3.205E-6 6.243E-5 3.336E-4 3.750E-4 7 570
7 GO:0005667 transcription factor complex 3.735E-6 6.243E-5 3.336E-4 4.370E-4 6 369
8 GO:0005677 chromatin silencing complex 4.931E-5 7.211E-4 3.853E-3 5.769E-3 2 9
9 GO:0016605 PML body 2.260E-4 2.939E-3 1.570E-2 2.645E-2 3 100
10 GO:0005720 nuclear heterochromatin 1.151E-3 1.277E-2
6.826E-2
1.347E-1
 2 42
11 GO:0097456 terminal loop 1.201E-3 1.277E-2
6.826E-2
1.405E-1
 1 1
12 GO:0044451 nucleoplasm part 1.574E-3 1.535E-2
8.202E-2
1.842E-1
 5 738
13 GO:1990622 CHOP-ATF3 complex 2.398E-3 2.158E-2
1.153E-1
2.806E-1
 1 2
14 GO:0033553 rDNA heterochromatin 4.790E-3 3.700E-2
1.977E-1
5.605E-1
 1 4
15 GO:0000792 heterochromatin 4.950E-3 3.700E-2
1.977E-1
5.791E-1
 2 88
16 GO:0000123 histone acetyltransferase complex 5.060E-3 3.700E-2
1.977E-1
5.920E-1
 2 89
17 GO:0033010 paranodal junction 5.985E-3 3.907E-2
2.088E-1
7.002E-1
 1 5
18 GO:0031248 protein acetyltransferase complex 6.345E-3 3.907E-2
2.088E-1
7.424E-1
 2 100
19 GO:1902493 acetyltransferase complex 6.345E-3 3.907E-2
2.088E-1
7.424E-1
 2 100
20 GO:0043219 lateral loop 8.369E-3 4.663E-2
2.492E-1
9.792E-1
 1 7
21 GO:0031931 TORC1 complex 8.369E-3 4.663E-2
2.492E-1
9.792E-1
 1 7
22 GO:0016604 nuclear body 9.343E-3 4.969E-2
2.655E-1
1.000E0
 3 368
Show 17 more annotations

4: Human Phenotype [Display Chart] 207 annotations before applied cutoff / 1813 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0000218 High palate 3.525E-4 3.487E-2
2.062E-1
7.296E-2
 3 129
2 HP:0000490 Deeply set eye 6.838E-4 3.487E-2
2.062E-1
1.415E-1
 2 28
3 HP:0000689 Dental malocclusion 1.074E-3 3.487E-2
2.062E-1
2.222E-1
 2 35
4 HP:0011220 Prominent forehead 1.624E-3 3.487E-2
2.062E-1
3.362E-1
 2 43
5 HP:0000938 Osteopenia 2.564E-3 3.487E-2
2.062E-1
5.307E-1
 2 54
6 HP:0000767 Pectus excavatum 2.757E-3 3.487E-2
2.062E-1
5.706E-1
 2 56
7 HP:0000280 Coarse facial features 2.856E-3 3.487E-2
2.062E-1
5.912E-1
 2 57
8 HP:0100710 Impulsivity 3.308E-3 3.487E-2
2.062E-1
6.847E-1
 1 2
9 HP:0010775 Vascular ring 3.308E-3 3.487E-2
2.062E-1
6.847E-1
 1 2
10 HP:0008107 Plantar crease between first and second toes 3.308E-3 3.487E-2
2.062E-1
6.847E-1
 1 2
11 HP:0004411 Deviated nasal septum 3.308E-3 3.487E-2
2.062E-1
6.847E-1
 1 2
12 HP:0100750 Atelectasis 3.308E-3 3.487E-2
2.062E-1
6.847E-1
 1 2
13 HP:0005895 Radial deviation of thumb terminal phalanx 3.308E-3 3.487E-2
2.062E-1
6.847E-1
 1 2
14 HP:0011087 Talon cusp 3.308E-3 3.487E-2
2.062E-1
6.847E-1
 1 2
15 HP:0006483 Abnormal number of teeth 3.308E-3 3.487E-2
2.062E-1
6.847E-1
 1 2
16 HP:0005306 Capillary hemangiomas 3.308E-3 3.487E-2
2.062E-1
6.847E-1
 1 2
17 HP:0005425 Recurrent sinopulmonary infections 3.308E-3 3.487E-2
2.062E-1
6.847E-1
 1 2
18 HP:0001561 Polyhydramnios 3.711E-3 3.487E-2
2.062E-1
7.681E-1
 2 65
19 HP:0001631 Atria septal defect 4.179E-3 3.487E-2
2.062E-1
8.651E-1
 2 69
20 HP:0000520 Proptosis 4.300E-3 3.487E-2
2.062E-1
8.902E-1
 2 70
21 HP:0010562 Keloids 4.959E-3 3.487E-2
2.062E-1
1.000E0
 1 3
22 HP:0001879 Abnormality of eosinophils 4.959E-3 3.487E-2
2.062E-1
1.000E0
 1 3
23 HP:0001042 High axial triradius 4.959E-3 3.487E-2
2.062E-1
1.000E0
 1 3
24 HP:0002750 Delayed skeletal maturation 5.468E-3 3.487E-2
2.062E-1
1.000E0
 2 79
25 HP:0002019 Constipation 5.606E-3 3.487E-2
2.062E-1
1.000E0
 2 80
26 HP:0004209 Clinodactyly of the 5th finger 6.030E-3 3.487E-2
2.062E-1
1.000E0
 2 83
27 HP:0000494 Downslanted palpebral fissures 6.469E-3 3.487E-2
2.062E-1
1.000E0
 2 86
28 HP:0000756 Agoraphobia 6.608E-3 3.487E-2
2.062E-1
1.000E0
 1 4
29 HP:0006335 Persistence of primary teeth 6.608E-3 3.487E-2
2.062E-1
1.000E0
 1 4
30 HP:0100703 Tongue thrusting 6.608E-3 3.487E-2
2.062E-1
1.000E0
 1 4
31 HP:0010807 Open bite 6.608E-3 3.487E-2
2.062E-1
1.000E0
 1 4
32 HP:0006114 Multiple palmar creases 6.608E-3 3.487E-2
2.062E-1
1.000E0
 1 4
33 HP:0009715 Papillary cystadenoma of the epididymis 6.608E-3 3.487E-2
2.062E-1
1.000E0
 1 4
34 HP:0002700 Large foramen magnum 6.608E-3 3.487E-2
2.062E-1
1.000E0
 1 4
35 HP:0002726 Recurrent Staphylococcus aureus infections 6.608E-3 3.487E-2
2.062E-1
1.000E0
 1 4
36 HP:0001212 Prominent fingertip pads 6.608E-3 3.487E-2
2.062E-1
1.000E0
 1 4
37 HP:0010314 Premature thelarche 6.608E-3 3.487E-2
2.062E-1
1.000E0
 1 4
38 HP:0008113 Multiple plantar creases 6.608E-3 3.487E-2
2.062E-1
1.000E0
 1 4
39 HP:0001335 Bimanual synkinesia 6.608E-3 3.487E-2
2.062E-1
1.000E0
 1 4
40 HP:0007333 Hypoplasia of the frontal lobes 8.255E-3 3.487E-2
2.062E-1
1.000E0
 1 5
41 HP:0009921 Duane anomaly 8.255E-3 3.487E-2
2.062E-1
1.000E0
 1 5
42 HP:0000976 Eczematoid dermatitis 8.255E-3 3.487E-2
2.062E-1
1.000E0
 1 5
43 HP:0000273 Facial grimacing 8.255E-3 3.487E-2
2.062E-1
1.000E0
 1 5
44 HP:0000136 Bifid uterus 8.255E-3 3.487E-2
2.062E-1
1.000E0
 1 5
45 HP:0009765 Low hanging columella 8.255E-3 3.487E-2
2.062E-1
1.000E0
 1 5
46 HP:0003319 Abnormality of the cervical spine 8.255E-3 3.487E-2
2.062E-1
1.000E0
 1 5
47 HP:0002617 Aneurysm 8.255E-3 3.487E-2
2.062E-1
1.000E0
 1 5
48 HP:0001135 Chorioretinal dystrophy 8.255E-3 3.487E-2
2.062E-1
1.000E0
 1 5
49 HP:0001047 Atopic dermatitis 8.255E-3 3.487E-2
2.062E-1
1.000E0
 1 5
50 HP:0002007 Frontal bossing 9.237E-3 3.748E-2
2.216E-1
1.000E0
 2 103
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 1458 annotations before applied cutoff / 9208 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0000715 decreased thymocyte number 1.292E-7 1.884E-4 1.481E-3 1.884E-4 7 180
2 MP:0012765 decreased alpha-beta T cell number 1.691E-6 1.233E-3 9.693E-3 2.466E-3 8 386
3 MP:0008075 decreased CD4-positive, alpha beta T cell number 3.805E-6 1.816E-3 1.428E-2 5.547E-3 7 297
4 MP:0005092 decreased double-positive T cell number 4.983E-6 1.816E-3 1.428E-2 7.265E-3 6 197
5 MP:0006042 increased apoptosis 7.352E-6 1.866E-3 1.467E-2 1.072E-2 10 823
6 MP:0012556 increased cell death 7.680E-6 1.866E-3 1.467E-2 1.120E-2 10 827
7 MP:0002408 abnormal double-positive T cell morphology 1.406E-5 2.542E-3 1.999E-2 2.051E-2 6 236
8 MP:0005018 decreased T cell number 1.463E-5 2.542E-3 1.999E-2 2.133E-2 9 691
9 MP:0002435 abnormal effector T cell morphology 1.569E-5 2.542E-3 1.999E-2 2.288E-2 9 697
10 MP:0013560 abnormal endocrine gland morphology 2.127E-5 3.051E-3 2.399E-2 3.102E-2 10 927
11 MP:0000703 abnormal thymus morphology 2.302E-5 3.051E-3 2.399E-2 3.356E-2 8 549
12 MP:0012762 abnormal alpha-beta T cell morphology 2.518E-5 3.059E-3 2.405E-2 3.671E-2 9 739
13 MP:0011086 postnatal lethality, incomplete penetrance 3.501E-5 3.660E-3 2.878E-2
5.105E-2
 9 770
14 MP:0012763 abnormal alpha-beta T cell number 3.515E-5 3.660E-3 2.878E-2
5.124E-2
 8 582
15 MP:0002145 abnormal T cell differentiation 3.842E-5 3.734E-3 2.936E-2
5.601E-2
 7 423
16 MP:0008073 abnormal CD4-positive, alpha beta T cell number 4.665E-5 4.251E-3 3.342E-2
6.802E-2
 7 436
17 MP:0008182 decreased marginal zone B cell number 6.745E-5 5.785E-3 4.549E-2
9.835E-2
 4 95
18 MP:0005605 increased bone mass 7.618E-5 6.171E-3 4.851E-2
1.111E-1
 4 98
19 MP:0005015 increased T cell number 1.086E-4 6.968E-3
5.479E-2
1.584E-1
 7 498
20 MP:0000352 decreased cell proliferation 1.114E-4 6.968E-3
5.479E-2
1.624E-1
 7 500
21 MP:0002432 abnormal CD4-positive, alpha beta T cell morphology 1.114E-4 6.968E-3
5.479E-2
1.624E-1
 7 500
22 MP:0006387 abnormal T cell number 1.140E-4 6.968E-3
5.479E-2
1.663E-1
 9 894
23 MP:0002006 neoplasm 1.181E-4 6.968E-3
5.479E-2
1.722E-1
 9 898
24 MP:0005136 decreased growth hormone level 1.190E-4 6.968E-3
5.479E-2
1.735E-1
 3 41
25 MP:0005093 decreased B cell proliferation 1.195E-4 6.968E-3
5.479E-2
1.742E-1
 4 110
26 MP:0002357 abnormal spleen white pulp morphology 1.265E-4 7.095E-3
5.578E-2
1.845E-1
 6 349
27 MP:0005090 increased double-negative T cell number 1.420E-4 7.666E-3
6.027E-2
2.070E-1
 4 115
28 MP:0008077 abnormal CD8-positive, alpha-beta T cell number 1.850E-4 9.632E-3
7.573E-2
2.697E-1
 6 374
29 MP:0008037 abnormal T cell morphology 2.047E-4 1.012E-2
7.957E-2
2.984E-1
 9 964
30 MP:0011704 decreased fibroblast proliferation 2.082E-4 1.012E-2
7.957E-2
3.036E-1
 4 127
31 MP:0008180 abnormal marginal zone B cell morphology 2.346E-4 1.103E-2
8.676E-2
3.421E-1
 4 131
32 MP:0005016 decreased lymphocyte cell number 2.550E-4 1.162E-2
9.136E-2
3.718E-1
 9 992
33 MP:0005010 abnormal CD8-positive, alpha beta T cell morphology 2.854E-4 1.261E-2
9.913E-2
4.161E-1
 6 405
34 MP:0002019 abnormal tumor incidence 3.439E-4 1.470E-2
1.156E-1
5.014E-1
 8 804
35 MP:0005336 abnormal inguinal fat pad morphology 3.529E-4 1.470E-2
1.156E-1
5.145E-1
 3 59
36 MP:0008079 decreased CD8-positive, alpha-beta T cell number 3.777E-4 1.526E-2
1.200E-1
5.507E-1
 5 272
37 MP:0002166 altered tumor susceptibility 3.872E-4 1.526E-2
1.200E-1
5.645E-1
 8 818
38 MP:0003968 abnormal growth hormone level 4.087E-4 1.568E-2
1.233E-1
5.958E-1
 3 62
39 MP:0008211 decreased mature B cell number 4.246E-4 1.586E-2
1.247E-1
6.191E-1
 5 279
40 MP:0002362 abnormal spleen marginal zone morphology 4.352E-4 1.586E-2
1.247E-1
6.345E-1
 4 154
41 MP:0002401 abnormal lymphopoiesis 4.854E-4 1.706E-2
1.341E-1
7.078E-1
 7 634
42 MP:0004700 abnormal circulating insulin-like growth factor I level 4.914E-4 1.706E-2
1.341E-1
7.165E-1
 3 66
43 MP:0008831 abnormal insulin-like growth factor I level 5.136E-4 1.742E-2
1.369E-1
7.489E-1
 3 67
44 MP:0008735 increased susceptibility to endotoxin shock 5.365E-4 1.778E-2
1.398E-1
7.822E-1
 3 68
45 MP:0005017 decreased B cell number 5.856E-4 1.875E-2
1.474E-1
8.539E-1
 6 463
46 MP:0011702 abnormal fibroblast proliferation 5.915E-4 1.875E-2
1.474E-1
8.624E-1
 4 167
47 MP:0005463 abnormal CD4-positive, alpha-beta T cell physiology 6.326E-4 1.962E-2
1.543E-1
9.223E-1
 4 170
48 MP:0005022 abnormal immature B cell morphology 6.756E-4 2.052E-2
1.614E-1
9.851E-1
 4 173
49 MP:0008568 abnormal interleukin secretion 7.170E-4 2.134E-2
1.678E-1
1.000E0
 6 481
50 MP:0005153 abnormal B cell proliferation 7.680E-4 2.239E-2
1.761E-1
1.000E0
 4 179
Show 45 more annotations

6: Domain [Display Chart] 201 annotations before applied cutoff / 16924 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF00170 bZIP 1 Pfam 1.170E-7 1.113E-5 6.549E-5 2.351E-5 4 34
2 IPR011616 bZIP 1 InterPro 1.170E-7 1.113E-5 6.549E-5 2.351E-5 4 34
3 IPR008917 Euk TF DNA-bd InterPro 1.661E-7 1.113E-5 6.549E-5 3.340E-5 4 37
4 PS00036 BZIP BASIC PROSITE 6.719E-7 2.085E-5 1.227E-4 1.351E-4 4 52
5 SM00338 BRLZ SMART 6.719E-7 2.085E-5 1.227E-4 1.351E-4 4 52
6 IPR004827 TF bZIP InterPro 7.261E-7 2.085E-5 1.227E-4 1.460E-4 4 53
7 PS50217 BZIP PROSITE 7.261E-7 2.085E-5 1.227E-4 1.460E-4 4 53
8 SM00432 MADS SMART 1.762E-5 3.220E-4 1.894E-3 3.542E-3 2 5
9 PS50066 MADS BOX 2 PROSITE 1.762E-5 3.220E-4 1.894E-3 3.542E-3 2 5
10 PS00350 MADS BOX 1 PROSITE 1.762E-5 3.220E-4 1.894E-3 3.542E-3 2 5
11 PF00319 SRF-TF Pfam 1.762E-5 3.220E-4 1.894E-3 3.542E-3 2 5
12 IPR002100 TF MADSbox InterPro 2.641E-5 4.424E-4 2.603E-3 5.309E-3 2 6
13 PF02146 SIR2 Pfam 3.695E-5 4.951E-4 2.913E-3 7.427E-3 2 7
14 PS50305 SIRTUIN PROSITE 3.695E-5 4.951E-4 2.913E-3 7.427E-3 2 7
15 IPR003000 NAD-dep histone deAcase SIR2 InterPro 3.695E-5 4.951E-4 2.913E-3 7.427E-3 2 7
16 IPR000837 Leuzip Fos InterPro 4.922E-5 6.184E-4 3.638E-3 9.894E-3 2 8
17 PF07716 bZIP 2 Pfam 2.373E-4 2.553E-3 1.502E-2 4.770E-2 2 17
18 IPR011700 bZIP 2 InterPro 2.373E-4 2.553E-3 1.502E-2 4.770E-2 2 17
19 PF00569 ZZ Pfam 2.668E-4 2.553E-3 1.502E-2
5.362E-2
 2 18
20 PS50135 ZF ZZ 2 PROSITE 2.668E-4 2.553E-3 1.502E-2
5.362E-2
 2 18
21 PS01357 ZF ZZ 1 PROSITE 2.668E-4 2.553E-3 1.502E-2
5.362E-2
 2 18
22 IPR000433 Znf ZZ InterPro 2.979E-4 2.603E-3 1.532E-2
5.988E-2
 2 19
23 SM00291 ZnF ZZ SMART 2.979E-4 2.603E-3 1.532E-2
5.988E-2
 2 19
24 PF08771 Rapamycin bind Pfam 1.361E-3 1.052E-2
6.189E-2
2.735E-1
 1 1
25 G3DSA:1.20.120.150 FRAP FKBP12 bd Gene3D 1.361E-3 1.052E-2
6.189E-2
2.735E-1
 1 1
26 IPR009076 FKBP rapamycin-assoc FKBP12-bd InterPro 1.361E-3 1.052E-2
6.189E-2
2.735E-1
 1 1
27 PF06001 DUF902 Pfam 2.716E-3 1.241E-2
7.300E-2
5.460E-1
 1 2
28 PF02172 KIX Pfam 2.716E-3 1.241E-2
7.300E-2
5.460E-1
 1 2
29 PS50134 ZF TAZ PROSITE 2.716E-3 1.241E-2
7.300E-2
5.460E-1
 1 2
30 PF09030 Creb binding Pfam 2.716E-3 1.241E-2
7.300E-2
5.460E-1
 1 2
31 IPR013178 Histone H3-K56 AcTrfase RTT109 InterPro 2.716E-3 1.241E-2
7.300E-2
5.460E-1
 1 2
32 G3DSA:1.10.246.20 KIX Gene3D 2.716E-3 1.241E-2
7.300E-2
5.460E-1
 1 2
33 IPR000163 Prohibitin InterPro 2.716E-3 1.241E-2
7.300E-2
5.460E-1
 1 2
34 G3DSA:1.10.1630.10 Nuc rcpt coact CREBbp Gene3D 2.716E-3 1.241E-2
7.300E-2
5.460E-1
 1 2
35 IPR017328 NAD-dep deAcase SIR2 euk InterPro 2.716E-3 1.241E-2
7.300E-2
5.460E-1
 1 2
36 PS50952 KIX PROSITE 2.716E-3 1.241E-2
7.300E-2
5.460E-1
 1 2
37 IPR014744 Nuc rcpt coact CREBbp InterPro 2.716E-3 1.241E-2
7.300E-2
5.460E-1
 1 2
38 IPR010303 DUF902 CREBbp InterPro 2.716E-3 1.241E-2
7.300E-2
5.460E-1
 1 2
39 IPR003101 KIX InterPro 2.716E-3 1.241E-2
7.300E-2
5.460E-1
 1 2
40 IPR000197 Znf TAZ InterPro 2.716E-3 1.241E-2
7.300E-2
5.460E-1
 1 2
41 PF02135 zf-TAZ Pfam 2.716E-3 1.241E-2
7.300E-2
5.460E-1
 1 2
42 G3DSA:1.20.1020.10 Znf TAZ Gene3D 2.716E-3 1.241E-2
7.300E-2
5.460E-1
 1 2
43 SM00551 ZnF TAZ SMART 2.716E-3 1.241E-2
7.300E-2
5.460E-1
 1 2
44 PF08214 KAT11 Pfam 2.716E-3 1.241E-2
7.300E-2
5.460E-1
 1 2
45 IPR005643 JNK InterPro 4.072E-3 1.705E-2
1.003E-1
8.184E-1
 1 3
46 PF03957 Jun Pfam 4.072E-3 1.705E-2
1.003E-1
8.184E-1
 1 3
47 IPR008356 Tyr Pase KIM-con InterPro 4.072E-3 1.705E-2
1.003E-1
8.184E-1
 1 3
48 IPR002112 Leuzip Jun InterPro 4.072E-3 1.705E-2
1.003E-1
8.184E-1
 1 3
49 IPR022102 HJURP C InterPro 5.425E-3 2.181E-2
1.283E-1
1.000E0
 1 4
50 PF12347 HJURP C Pfam 5.425E-3 2.181E-2
1.283E-1
1.000E0
 1 4
Show 45 more annotations

7: Pathway [Display Chart] 524 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 711361 Oncostatin M Signaling Pathway BioSystems: WikiPathways 1.032E-7 2.714E-5 1.856E-4 5.410E-5 5 63
2 P00047 PDGF signaling pathway PantherDB 1.036E-7 2.714E-5 1.856E-4 5.428E-5 6 127
3 672462 Prolactin Signaling Pathway BioSystems: WikiPathways 2.498E-7 4.268E-5 2.919E-4 1.309E-4 5 75
4 198774 TGF-beta Receptor Signaling Pathway BioSystems: WikiPathways 3.258E-7 4.268E-5 2.919E-4 1.707E-4 6 154
5 137955 ErbB2/ErbB3 signaling events BioSystems: Pathway Interaction Database 5.099E-7 5.343E-5 3.655E-4 2.672E-4 4 35
6 P00036 Interleukin signaling pathway PantherDB 6.971E-7 6.088E-5 4.164E-4 3.653E-4 5 92
7 198864 IL-6 Signaling Pathway BioSystems: WikiPathways 1.005E-6 7.524E-5 5.146E-4 5.267E-4 5 99
8 138057 ErbB1 downstream signaling BioSystems: Pathway Interaction Database 1.224E-6 8.019E-5 5.485E-4 6.415E-4 5 103
9 138006 ATF-2 transcription factor network BioSystems: Pathway Interaction Database 3.239E-6 1.772E-4 1.212E-3 1.697E-3 4 55
10 M4835 B Cell Survival Pathway MSigDB C2 BIOCARTA (v5.1) 3.382E-6 1.772E-4 1.212E-3 1.772E-3 3 16
11 83117 Acute myeloid leukemia BioSystems: KEGG 3.742E-6 1.783E-4 1.219E-3 1.961E-3 4 57
12 712093 BDNF signaling pathway BioSystems: WikiPathways 6.396E-6 2.684E-4 1.836E-3 3.352E-3 5 144
13 694606 Hepatitis B BioSystems: KEGG 6.843E-6 2.684E-4 1.836E-3 3.586E-3 5 146
14 137997 Signaling events mediated by HDAC Class I BioSystems: Pathway Interaction Database 7.172E-6 2.684E-4 1.836E-3 3.758E-3 4 67
15 M5489 IL 6 signaling pathway MSigDB C2 BIOCARTA (v5.1) 9.231E-6 3.225E-4 2.206E-3 4.837E-3 3 22
16 198779 MAPK signaling pathway BioSystems: WikiPathways 1.279E-5 4.190E-4 2.866E-3 6.704E-3 5 166
17 198782 EGFR1 Signaling Pathway BioSystems: WikiPathways 1.746E-5 5.382E-4 3.681E-3 9.150E-3 5 177
18 83105 Pathways in cancer BioSystems: KEGG 2.559E-5 7.044E-4 4.818E-3 1.341E-2 6 327
19 M1909 EGF Signaling Pathway MSigDB C2 BIOCARTA (v5.1) 2.664E-5 7.044E-4 4.818E-3 1.396E-2 3 31
20 M2529 PDGF Signaling Pathway MSigDB C2 BIOCARTA (v5.1) 2.936E-5 7.044E-4 4.818E-3 1.539E-2 3 32
21 106401 MyD88-independent cascade BioSystems: REACTOME 3.123E-5 7.044E-4 4.818E-3 1.636E-2 4 97
22 106391 Toll Like Receptor 3 (TLR3) Cascade BioSystems: REACTOME 3.123E-5 7.044E-4 4.818E-3 1.636E-2 4 97
23 106459 NGF signalling via TRKA from the plasma membrane BioSystems: REACTOME 3.223E-5 7.044E-4 4.818E-3 1.689E-2 5 201
24 198836 Signaling of Hepatocyte Growth Factor Receptor BioSystems: WikiPathways 3.226E-5 7.044E-4 4.818E-3 1.690E-2 3 33
25 833821 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production BioSystems: REACTOME 3.513E-5 7.122E-4 4.871E-3 1.841E-2 2 5
26 169349 Validated transcriptional targets of AP1 family members Fra1 and Fra2 BioSystems: Pathway Interaction Database 3.534E-5 7.122E-4 4.871E-3 1.852E-2 3 34
27 695200 HIF-1 signaling pathway BioSystems: KEGG 4.427E-5 8.556E-4 5.852E-3 2.320E-2 4 106
28 M19358 Signaling of Hepatocyte Growth Factor Receptor MSigDB C2 BIOCARTA (v5.1) 4.572E-5 8.556E-4 5.852E-3 2.396E-2 3 37
29 755440 Prostate Cancer BioSystems: WikiPathways 4.939E-5 8.659E-4 5.922E-3 2.588E-2 4 109
30 672451 TSLP Signaling Pathway BioSystems: WikiPathways 4.957E-5 8.659E-4 5.922E-3 2.598E-2 3 38
31 137972 Signaling events mediated by HDAC Class III BioSystems: Pathway Interaction Database 5.364E-5 9.067E-4 6.201E-3 2.811E-2 3 39
32 138040 IFN-gamma pathway BioSystems: Pathway Interaction Database 5.792E-5 9.484E-4 6.487E-3 3.035E-2 3 40
33 198885 IL-2 Signaling pathway BioSystems: WikiPathways 6.713E-5 1.066E-3 7.291E-3 3.518E-2 3 42
34 137932 IL6-mediated signaling events BioSystems: Pathway Interaction Database 7.207E-5 1.111E-3 7.597E-3 3.777E-2 3 43
35 M19784 T Cell Receptor Signaling Pathway MSigDB C2 BIOCARTA (v5.1) 9.423E-5 1.411E-3 9.649E-3 4.938E-2 3 47
36 198907 Energy Metabolism BioSystems: WikiPathways 1.004E-4 1.448E-3 9.907E-3
5.260E-2
 3 48
37 160135 MAP kinase activation in TLR cascade BioSystems: REACTOME 1.068E-4 1.448E-3 9.907E-3
5.597E-2
 3 49
38 920993 Interferon type I BioSystems: WikiPathways 1.068E-4 1.448E-3 9.907E-3
5.597E-2
 3 49
39 83048 MAPK signaling pathway BioSystems: KEGG 1.078E-4 1.448E-3 9.907E-3
5.649E-2
 5 259
40 138018 Downstream signaling in naive CD8+ T cells BioSystems: Pathway Interaction Database 1.135E-4 1.481E-3 1.013E-2
5.946E-2
 3 50
41 373901 HTLV-I infection BioSystems: KEGG 1.159E-4 1.481E-3 1.013E-2
6.072E-2
 5 263
42 477120 Signaling by SCF-KIT BioSystems: REACTOME 1.238E-4 1.520E-3 1.040E-2
6.489E-2
 4 138
43 137976 IL2-mediated signaling events BioSystems: Pathway Interaction Database 1.276E-4 1.520E-3 1.040E-2
6.688E-2
 3 52
44 138068 Signaling events mediated by Stem cell factor receptor (c-Kit) BioSystems: Pathway Interaction Database 1.276E-4 1.520E-3 1.040E-2
6.688E-2
 3 52
45 833826 FCERI mediated MAPK activation BioSystems: REACTOME 1.351E-4 1.574E-3 1.076E-2
7.081E-2
 3 53
46 672447 RANKL/RANK Signaling Pathway BioSystems: WikiPathways 1.429E-4 1.628E-3 1.113E-2
7.488E-2
 3 54
47 198810 TGF Beta Signaling Pathway BioSystems: WikiPathways 1.510E-4 1.683E-3 1.151E-2
7.910E-2
 3 55
48 137916 Regulation of retinoblastoma protein BioSystems: Pathway Interaction Database 1.593E-4 1.739E-3 1.190E-2
8.348E-2
 3 56
49 106439 Signalling by NGF BioSystems: REACTOME 1.663E-4 1.778E-3 1.216E-2
8.712E-2
 5 284
50 P00010 B cell activation PantherDB 1.769E-4 1.854E-3 1.268E-2
9.269E-2
 3 58
Show 45 more annotations

8: Pubmed [Display Chart] 12668 annotations before applied cutoff / 51818 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Pubmed 1.248E-12 1.581E-8 1.585E-7 1.581E-8 10 849
2 19270680 CBP/p300-mediated acetylation of histone H3 on lysine 56. Pubmed 7.633E-10 4.440E-6 4.451E-5 9.670E-6 3 5
3 20102225 Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays. Pubmed 1.051E-9 4.440E-6 4.451E-5 1.332E-5 4 32
4 24419059 CBP-mediated FOXO-1 acetylation inhibits pancreatic tumor growth by targeting SirT. Pubmed 1.526E-9 4.833E-6 4.845E-5 1.933E-5 3 6
5 21937452 Binding site specificity and factor redundancy in activator protein-1-driven human papillomavirus chromatin-dependent transcription. Pubmed 4.271E-9 1.082E-5 1.085E-4 5.410E-5 3 8
6 15276183 MD-2: the Toll 'gatekeeper' in endotoxin signalling. Pubmed 3.323E-8 5.081E-5 5.094E-4 4.210E-4 4 74
7 25063062 Effects of mTOR-STAT3 on the migration and invasion abilities of hepatoma cell and mTOR-STAT3 expression in liver cancer. Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
8 23900402 Discovery of a potent small molecule SIRT1/2 inhibitor with anticancer effects. Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
9 16210620:gr Protein acetylation regulates both PU.1 transactivation and Ig kappa 3' enhancer activity. GeneRIF 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
10 19331815:gr mTOR mediates human trophoblast invasion through regulation of matrix-remodeling enzymes and is associated with serine phosphorylation of STAT3. GeneRIF 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
11 25341037 SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth. Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
12 22796962 Differential sirtuin expression patterns in amyotrophic lateral sclerosis (ALS) postmortem tissue: neuroprotective or neurotoxic properties of sirtuins in ALS? Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
13 11859076:gr Vav1 couples T cell receptor to serum response factor-dependent transcription via a MEK-dependent pathway. GeneRIF 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
14 11859076 Vav1 couples T cell receptor to serum response factor-dependent transcription via a MEK-dependent pathway. Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
15 1589769 Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos. Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
16 21292826:gr GnRH induces the c-Fos gene via phosphorylation of SRF by the calcium/calmodulin kinase II pathway. GeneRIF 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
17 18722353:gr Acetylation of Sirt2 by p300 attenuates its deacetylase activity. GeneRIF 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
18 15632193:gr SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. GeneRIF 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
19 21471201:gr Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1. GeneRIF 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
20 19295512:gr STAT3 inhibition of gluconeogenesis is downregulated by SirT1. GeneRIF 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
21 25924011 Resveratrol Induced Premature Senescence Is Associated with DNA Damage Mediated SIRT1 and SIRT2 Down-Regulation. Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
22 17531086:gr Role of c-Fos/JunD in protecting stress-induced cell death. GeneRIF 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
23 12193410 An activator protein-1 complex mediates epidermal growth factor regulation of equine glycoprotein alpha subunit expression in trophoblast cells. Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
24 25915617 Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients. Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
25 24687132 Disruption of mammalian target of rapamycin complex 1 in macrophages decreases chemokine gene expression and atherosclerosis. Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
26 10434034 Transcriptional activation of the F(1)F(0) ATP synthase alpha-subunit initiator element by USF2 is mediated by p300. Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
27 25632225 Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells. Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
28 20042677:gr A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis. GeneRIF 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
29 21768204:gr Sindbis virus induced phosphorylation of IRF3 in human embryonic kidney cells is not dependent on mTOR. GeneRIF 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
30 22174410:gr Nuclear factor erythroid-derived 2 (Nfe2) regulates JunD DNA-binding activity via acetylation: a novel mechanism regulating trophoblast differentiation. GeneRIF 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
31 12473110:gr Transcriptional activity of interferon regulatory factor (IRF)-3 depends on multiple protein-protein interactions. GeneRIF 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
32 21768204 Sindbis virus induced phosphorylation of IRF3 in human embryonic kidney cells is not dependent on mTOR. Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
33 21467030:gr Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein. GeneRIF 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
34 11724783:gr The Small RNA gene activator protein, SphI postoctamer homology-binding factor/selenocysteine tRNA gene transcription activating factor, stimulates transcription of the human interferon regulatory factor-3 gene. GeneRIF 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
35 18995842:gr The SIRT2 deacetylase regulates autoacetylation of p300. GeneRIF 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
36 19331815 mTOR mediates human trophoblast invasion through regulation of matrix-remodeling enzymes and is associated with serine phosphorylation of STAT3. Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
37 24064760 Resveratrol suppresses the STAT3 signaling pathway and inhibits proliferation of high glucose-exposed HepG2 cells partly through SIRT1. Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
38 8152431 Activating transcription factor-3 stimulates 3',5'-cyclic adenosine monophosphate-dependent gene expression. Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
39 18995842 The SIRT2 deacetylase regulates autoacetylation of p300. Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
40 12600988:gr Independent and cooperative activation of chromosomal c-fos promoter by STAT3. GeneRIF 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
41 15649887:gr Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation. GeneRIF 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
42 26191214 Glycyrrhizic acid inhibits leukemia cell growth and migration via blocking AKT/mTOR/STAT3 signaling. Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
43 25847123 SirT1 and STAT3 protect retinal pigmented epithelium cells against oxidative stress. Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
44 11724783 The Small RNA gene activator protein, SphI postoctamer homology-binding factor/selenocysteine tRNA gene transcription activating factor, stimulates transcription of the human interferon regulatory factor-3 gene. Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
45 12600988 Independent and cooperative activation of chromosomal c-fos promoter by STAT3. Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
46 10660304 Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR. Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
47 26307266 Resveratrol via sirtuin-1 downregulates RE1-silencing transcription factor (REST) expression preventing PCB-95-induced neuronal cell death. Pubmed 1.885E-7 5.081E-5 5.094E-4 2.388E-3 2 2
48 18255255 A protein-protein interaction network of transcription factors acting during liver cell proliferation. Pubmed 2.770E-7 7.020E-5 7.036E-4 3.509E-3 3 29
49 25794641 Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells. Pubmed 5.652E-7 7.020E-5 7.036E-4 7.160E-3 2 3
50 15292274 Molecular cross-talk between MEK1/2 and mTOR signaling during recovery of 293 cells from hypertonic stress. Pubmed 5.652E-7 7.020E-5 7.036E-4 7.160E-3 2 3
Show 45 more annotations

9: Interaction [Display Chart] 1589 annotations before applied cutoff / 16535 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:FOS FOS interactions 6.372E-13 1.013E-9 8.048E-9 1.013E-9 9 167
2 int:MAPK8 MAPK8 interactions 4.265E-12 3.389E-9 2.693E-8 6.777E-9 9 206
3 int:JUND JUND interactions 3.686E-11 1.625E-8 1.292E-7 5.857E-8 6 47
4 int:JUN JUN interactions 4.092E-11 1.625E-8 1.292E-7 6.502E-8 9 265
5 int:HDAC3 HDAC3 interactions 4.121E-10 1.268E-7 1.008E-6 6.548E-7 8 224
6 int:EP300 EP300 interactions 4.789E-10 1.268E-7 1.008E-6 7.610E-7 10 501
7 int:SIRT1 SIRT1 interactions 6.667E-10 1.513E-7 1.203E-6 1.059E-6 8 238
8 int:MYOD1 MYOD1 interactions 3.674E-9 7.297E-7 5.800E-6 5.838E-6 6 99
9 int:MAPK1 MAPK1 interactions 4.837E-9 8.539E-7 6.787E-6 7.685E-6 8 306
10 int:RELA RELA interactions 6.223E-9 9.888E-7 7.859E-6 9.888E-6 8 316
11 int:MEF2A MEF2A interactions 1.427E-8 2.062E-6 1.639E-5 2.268E-5 5 58
12 int:FHL2 FHL2 interactions 1.816E-8 2.309E-6 1.835E-5 2.886E-5 6 129
13 int:PML PML interactions 2.164E-8 2.309E-6 1.835E-5 3.438E-5 7 235
14 int:CREBBP CREBBP interactions 2.176E-8 2.309E-6 1.835E-5 3.458E-5 8 371
15 int:ATF3 ATF3 interactions 2.180E-8 2.309E-6 1.835E-5 3.464E-5 5 63
16 int:SIRT2 SIRT2 interactions 2.557E-8 2.539E-6 2.018E-5 4.063E-5 5 65
17 int:NFATC1 NFATC1 interactions 6.888E-8 6.438E-6 5.117E-5 1.095E-4 5 79
18 int:NFKB1 NFKB1 interactions 1.012E-7 8.934E-6 7.101E-5 1.608E-4 6 172
19 int:TBP TBP interactions 1.462E-7 1.222E-5 9.715E-5 2.322E-4 6 183
20 int:CEBPB CEBPB interactions 1.655E-7 1.315E-5 1.045E-4 2.630E-4 5 94
21 int:MEF2C MEF2C interactions 3.074E-7 2.326E-5 1.849E-4 4.885E-4 4 42
22 int:ASCL1 ASCL1 interactions 8.472E-7 6.119E-5 4.864E-4 1.346E-3 3 14
23 int:RB1 RB1 interactions 9.814E-7 6.780E-5 5.389E-4 1.559E-3 6 253
24 int:FOSB FOSB interactions 1.058E-6 6.848E-5 5.443E-4 1.681E-3 3 15
25 int:NFYA NFYA interactions 1.148E-6 6.848E-5 5.443E-4 1.824E-3 4 58
26 int:HNF1A HNF1A interactions 1.148E-6 6.848E-5 5.443E-4 1.824E-3 4 58
27 int:YY1 YY1 interactions 1.164E-6 6.848E-5 5.443E-4 1.849E-3 5 139
28 int:SPI1 SPI1 interactions 1.231E-6 6.983E-5 5.551E-4 1.955E-3 4 59
29 int:HDAC4 HDAC4 interactions 1.434E-6 7.856E-5 6.244E-4 2.278E-3 5 145
30 int:STAT3 STAT3 interactions 1.496E-6 7.925E-5 6.299E-4 2.378E-3 6 272
31 int:CREB1 CREB1 interactions 2.056E-6 1.054E-4 8.378E-4 3.267E-3 5 156
32 int:FOXO1 FOXO1 interactions 2.316E-6 1.150E-4 9.141E-4 3.680E-3 4 69
33 int:DDIT3 DDIT3 interactions 2.905E-6 1.358E-4 1.079E-3 4.616E-3 4 73
34 int:NFE2L2 NFE2L2 interactions 2.905E-6 1.358E-4 1.079E-3 4.616E-3 4 73
35 int:BATF BATF interactions 3.076E-6 1.397E-4 1.110E-3 4.888E-3 3 21
36 int:BATF3 BATF3 interactions 3.559E-6 1.571E-4 1.248E-3 5.654E-3 3 22
37 int:ATF4 ATF4 interactions 4.630E-6 1.952E-4 1.552E-3 7.357E-3 4 82
38 int:HOXA10 HOXA10 interactions 4.668E-6 1.952E-4 1.552E-3 7.418E-3 3 24
39 int:GATA1 GATA1 interactions 5.098E-6 1.997E-4 1.588E-3 8.101E-3 4 84
40 int:USF2 USF2 interactions 5.300E-6 1.997E-4 1.588E-3 8.422E-3 3 25
41 int:MAF MAF interactions 5.300E-6 1.997E-4 1.588E-3 8.422E-3 3 25
42 int:HDAC2 HDAC2 interactions 5.342E-6 1.997E-4 1.588E-3 8.488E-3 6 339
43 int:STAT1 STAT1 interactions 5.405E-6 1.997E-4 1.588E-3 8.589E-3 5 190
44 int:RUNX3 RUNX3 interactions 5.986E-6 2.162E-4 1.718E-3 9.512E-3 3 26
45 int:BRCA1 BRCA1 interactions 6.220E-6 2.196E-4 1.746E-3 9.883E-3 7 544
46 int:HDAC1 HDAC1 interactions 6.764E-6 2.337E-4 1.857E-3 1.075E-2 7 551
47 int:PIK3R1 PIK3R1 interactions 1.032E-5 3.488E-4 2.772E-3 1.639E-2 5 217
48 int:FOSL1 FOSL1 interactions 1.248E-5 4.132E-4 3.284E-3 1.983E-2 3 33
49 int:NCOA1 NCOA1 interactions 1.436E-5 4.565E-4 3.629E-3 2.283E-2 4 109
50 int:KAT2A KAT2A interactions 1.436E-5 4.565E-4 3.629E-3 2.283E-2 4 109
Show 45 more annotations

10: Cytoband [Display Chart] 21 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19q13 19q13 2.333E-4 4.898E-3 1.786E-2 4.898E-3 2 34
2 16q21-q22.3 16q21-q22.3 6.640E-4 6.972E-3 2.542E-2 1.394E-2 1 1
3 1p36.2 1p36.2 8.594E-3 3.698E-2
1.348E-1
1.805E-1
 1 13
4 19q13.3-q13.4 19q13.3-q13.4 8.594E-3 3.698E-2
1.348E-1
1.805E-1
 1 13
5 19p13.2 19p13.2 1.054E-2 3.698E-2
1.348E-1
2.214E-1
 2 235
6 15q26 15q26 1.057E-2 3.698E-2
1.348E-1
2.219E-1
 1 16
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 309 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 TAAYNRNNTCC UNKNOWN TAAYNRNNTCC UNKNOWN 2.170E-4 3.896E-2
2.459E-1
6.705E-2
 4 143
2 V$VDR Q3 V$VDR Q3 6.027E-4 3.896E-2
2.459E-1
1.862E-1
 4 187
3 V$AP2ALPHA 01 V$AP2ALPHA 01 7.056E-4 3.896E-2
2.459E-1
2.180E-1
 4 195
4 V$AP2 Q6 V$AP2 Q6 7.906E-4 3.896E-2
2.459E-1
2.443E-1
 4 201
5 V$AP2GAMMA 01 V$AP2GAMMA 01 7.906E-4 3.896E-2
2.459E-1
2.443E-1
 4 201
6 V$YY1 01 V$YY1 01 8.512E-4 3.896E-2
2.459E-1
2.630E-1
 4 205
7 V$CREB Q2 V$CREB Q2 8.827E-4 3.896E-2
2.459E-1
2.727E-1
 4 207
8 V$ETS2 B V$ETS2 B 1.108E-3 4.279E-2
2.701E-1
3.423E-1
 4 220
Show 3 more annotations

12: Gene Family [Display Chart] 2 annotations before applied cutoff / 6751 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ZZZ Zinc fingers, ZZ-type genenames.org 2.664E-3 5.329E-3 7.993E-3 5.329E-3 1 6
2 ZNF Zinc fingers, C2H2-type genenames.org 1.648E-2 1.648E-2 2.472E-2 3.296E-2 2 514

13: Coexpression [Display Chart] 2121 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M6752 Genes essential to the development of megakaryocytes, as expressed in normal cells and essential thrombocythemic cells (ET). MSigDB C2: CGP Curated Gene Sets (v5.1) 6.418E-7 1.361E-3 1.121E-2 1.361E-3 4 66
2 M1361 Genes up-regulated in SCC12B2 cells (squamous cell carcinoma) by UV-B irradiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.770E-6 5.812E-3 4.788E-2 1.648E-2 4 123
3 M2492 Examples of transcription factors whose activities are regulated by MAPK11 [GeneID=5600] phosphorylation. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.056E-5 5.812E-3 4.788E-2 2.240E-2 2 5
4 M15154 Interaction partners of class IIa histone deacetylases (HDAC). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.309E-5 5.812E-3 4.788E-2 2.776E-2 3 44
5 M6782 Genes up-regulated in T24 (bladder cancer) cells in response to the photodynamic therapy (PDT) stress. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.370E-5 5.812E-3 4.788E-2 2.906E-2 7 811
6 M11218 Examples of transcription factors whose activities are regulated by MAPK7 [GeneID=5598] phosphorylation. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.952E-5 9.634E-3
7.936E-2
6.261E-2
 2 8
7 M3590 Integrin signaling signature in precursor B leukemia (PBL) cells: fibronectin (FN1) [GeneID=2335] vs control treatment with poly-L-lysine. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.180E-5 9.634E-3
7.936E-2
6.744E-2
 3 59
8 M14718 Examples of transcription factors whose activities are regulated by MAPK14 [GeneID=1432] phosphorylation. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.738E-5 1.113E-2
9.167E-2
1.005E-1
 2 10
9 M5201 Genes down-regulated in comparison of dendritic cells (DC) exposed to L. donovani versus DCs exposed to 50 worm/well B. malayi. MSigDB C7: Immunologic Signatures (v5.1) 5.247E-5 1.113E-2
9.167E-2
1.113E-1
 4 200
10 GSE43700 UNTREATED VS IL10 TREATED PBMC UP Genes up-regulated in peripheral blood monocytes (PBMC): control versus IL10 [GeneID=3586]. MSigDB C7: Immunologic Signatures (v5.1) 5.247E-5 1.113E-2
9.167E-2
1.113E-1
 4 200
11 M4517 Genes up-regulated in multiple myeloma (MM) compared to normal plasma cells from the patient's identical twin. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.220E-5 1.585E-2
1.306E-1
1.743E-1
 3 81
12 M6267 An assortment of osteoblast transcriptional regulators. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.556E-5 1.689E-2
1.391E-1
2.027E-1
 2 14
13 M19693 Genes up-regulated in NHEK cells (normal keratinocytes) by UV-B irradiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.133E-4 1.849E-2
1.523E-1
2.404E-1
 4 244
14 M15626 Genes up-regulated during prostate cancer progression in mice heterozygotic for both NKX3.1 and PTEN [GeneID=4824;5728]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.988E-4 2.882E-2
2.374E-1
4.216E-1
 2 20
15 M1309 Genes down-regulated in SEND cells (skin endothelium) at hypoxia after knockdown of HIF1A [GeneID=3091] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.038E-4 2.882E-2
2.374E-1
4.323E-1
 3 110
16 M13984 Genes up-regulated by IL2 [GeneID=3558] in cells derived from CD4+ [GeneID=920] cutaneous T-cell lymphoma (CTCL). MSigDB C2: CGP Curated Gene Sets (v5.1) 2.324E-4 3.011E-2
2.480E-1
4.929E-1
 3 115
17 M6868 Genes up-regulated in bone marrow hematopoietic stem cells (HSC, CD34+ [GeneID=947]) from patients with low risk of myelodysplastic syndrome (MDS) compared with healthy controls. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.413E-4 3.011E-2
2.480E-1
5.119E-1
 2 22
18 GSE13522 WT VS IFNG KO SKING T CRUZI Y STRAIN INF DN Genes down-regulated in skin after injection of Trypanosoma cruzi (strain Y): wildtype (BALB/c) versus INFG [GeneID=3458] knockout. MSigDB C7: Immunologic Signatures (v5.1) 2.901E-4 3.415E-2
2.813E-1
6.153E-1
 3 124
19 M2340 Top genes up-regulated in HEK293 cells (fibroblast) in response to trichostatin A (TSA) [PubChemID=5562]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.223E-4 3.415E-2
2.813E-1
8.957E-1
 2 29
20 M19270 Genes up-regulated by tretinoin (ATRA) [PubChem=444795] in U937 cells (acute promyelocytic leukemia, APL) made sensitive to the drug by expression of the PML-RARA fusion [GeneID=5371;5914]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.522E-4 3.415E-2
2.813E-1
9.590E-1
 2 30
21 M5622 Cluster G2: genes increasingly up-regulated in NHEK cells (normal keratinocyte) and reaching maximum levels at 12 h and 24 h after UV-B irradiation. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.522E-4 3.415E-2
2.813E-1
9.590E-1
 2 30
22 M11519 Genes whose expression peaked at 40 min after stimulation of MCF10A cells with serum. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.149E-4 3.415E-2
2.813E-1
1.000E0
 2 32
23 M14591 Oxidative stress genes down-regulated in ARPE-19 cells (retinal pigmented epithelium) in response to HNE, tBH and H2O2 [PubChem=5283344;6410;784]. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.165E-4 3.415E-2
2.813E-1
1.000E0
 2 35
24 GSE21360 SECONDARY VS QUATERNARY MEMORY CD8 TCELL DN Genes down-regulated in memory CD8 T cells: 2' versus 4'. MSigDB C7: Immunologic Signatures (v5.1) 6.339E-4 3.415E-2
2.813E-1
1.000E0
 3 162
25 M3649 Genes up-regulated in primary fibroblast cell culture point after infection with HCMV (AD169 strain) at 2 h time point that were not up-regulated at the previous time point, 1 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.658E-4 3.415E-2
2.813E-1
1.000E0
 2 39
26 M1999 The 'adult tissue stem' module: genes coordinately up-regulated in a compendium of adult tissue stem cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.889E-4 3.415E-2
2.813E-1
1.000E0
 5 721
27 M11585 Genes up-regulated in MCF7 cells (breast cancer) after stimulation with NRG1 [GeneID=3084]. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.931E-4 3.415E-2
2.813E-1
1.000E0
 3 175
28 M2365 Genes down-regulated in HEK-293 cells (fibroblast) upon knockdown of both CTBP1 and SATB1 [GeneID=1487, 6304] by RNAi. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.605E-4 3.415E-2
2.813E-1
1.000E0
 3 180
29 GSE7219 WT VS NIK NFKB2 KO DC UP Genes up-regulated in dendritic cells: wildtype versus NFKB2 [GeneID=4791]. MSigDB C7: Immunologic Signatures (v5.1) 9.170E-4 3.415E-2
2.813E-1
1.000E0
 3 184
30 M4723 Genes down-regulated in normal hematopoietic progenitors by RUNX1-RUNX1T1 [GeneID=861;862] fusion. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.461E-4 3.415E-2
2.813E-1
1.000E0
 3 186
31 GSE7219 UNSTIM VS LPS AND ANTI CD40 STIM NIK NFKB2 KO DC DN Genes down-regulated in dendritic cell NIK NFkB2-KO versus dendritic cell NIK NFkB2-KO LPS and anti-CD40 stimulated. MSigDB C7: Immunologic Signatures (v5.1) 9.757E-4 3.415E-2
2.813E-1
1.000E0
 3 188
32 M2819 Genes up-regulated in Sez-4 cells (T lymphocyte) that were first starved of IL2 [Gene ID=3558] and then stimulated with IL15 [Gene ID=3600]. MSigDB C6: Oncogenic Signatures (v5.1) 1.006E-3 3.415E-2
2.813E-1
1.000E0
 3 190
33 M1658 Upregulated in the gastrocnemius muscle of aged adult mice (30-month) vs young adult (5-month) MSigDB C2: CGP Curated Gene Sets (v5.1) 1.019E-3 3.415E-2
2.813E-1
1.000E0
 2 45
34 M17043 Top 50 genes down-regulated in metastatic vs primary prostate cancer tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.019E-3 3.415E-2
2.813E-1
1.000E0
 2 45
35 M1897 Cluster 1: ATM [GeneID=472] dependent genes induced at 30 min after ionizing radiation treatment. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.019E-3 3.415E-2
2.813E-1
1.000E0
 2 45
36 M2822 Genes up-regulated in Sez-4 cells (T lymphocyte) that were first starved of IL2 [Gene ID=3558] and then stimulated with IL2 [Gene ID=3558]. MSigDB C6: Oncogenic Signatures (v5.1) 1.021E-3 3.415E-2
2.813E-1
1.000E0
 3 191
37 GSE27291 0H VS 7D STIM GAMMADELTA TCELL DN Genes down-regulated in gamma delta T cells activated by phophoantigen BrHPP and IL2 [GeneID=3558]: 0h versus 7 days. MSigDB C7: Immunologic Signatures (v5.1) 1.084E-3 3.415E-2
2.813E-1
1.000E0
 3 195
38 M4926 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee before vaccination versus that after the vaccination. MSigDB C7: Immunologic Signatures (v5.1) 1.100E-3 3.415E-2
2.813E-1
1.000E0
 3 196
39 GSE20500 CTRL VS RARA ANTAGONIST TREATED CD4 TCELL UP Genes up-regulated in CD4 [GeneID=920] T cells: control versus Ro 41-5253 [PubChem=5312120]. MSigDB C7: Immunologic Signatures (v5.1) 1.117E-3 3.415E-2
2.813E-1
1.000E0
 3 197
40 M6103 Genes up-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: TGFB1 and IL4 [GeneID=7040;3565] (6h) versus IL4 [GeneID=3565] (6h). MSigDB C7: Immunologic Signatures (v5.1) 1.117E-3 3.415E-2
2.813E-1
1.000E0
 3 197
41 M10828 Human orthologs of genes up-regulated in the crb ('crash and burn') zebrafish mutant that represents a loss-of-function mutation in BMYB [GeneID=4605]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.117E-3 3.415E-2
2.813E-1
1.000E0
 3 197
42 M3519 Genes up-regulated in comparison of CD2+ plasmacytoid dendritic cells (DC) versus CD2- cells. MSigDB C7: Immunologic Signatures (v5.1) 1.133E-3 3.415E-2
2.813E-1
1.000E0
 3 198
43 M5405 Genes down-regulated in comparison of eosinophils versus neutrophils. MSigDB C7: Immunologic Signatures (v5.1) 1.133E-3 3.415E-2
2.813E-1
1.000E0
 3 198
44 GSE30971 WBP7 HET VS KO MACROPHAGE 2H LPS STIM DN Genes down-regulated in bone marrow-derived macrophages treated with LPS for 2h: heterozygous versus homozygous knockout of MLL4 [GeneID=9757]. MSigDB C7: Immunologic Signatures (v5.1) 1.150E-3 3.415E-2
2.813E-1
1.000E0
 3 199
45 M6045 Genes down-regulated in CD4 [GeneID=920] T cells: untreated (0h) versus activated by anti-CD3 and anti-CD28 and then stimulated by IL-12 (48h). MSigDB C7: Immunologic Signatures (v5.1) 1.150E-3 3.415E-2
2.813E-1
1.000E0
 3 199
46 M6073 Genes down-regulated in CD4 [GeneID=920] T cells: untreated (0h) versus activated by anti-CD3 and anti-CD28 (48h). MSigDB C7: Immunologic Signatures (v5.1) 1.150E-3 3.415E-2
2.813E-1
1.000E0
 3 199
47 M6992 Genes up-regulated in allogeneic T cells after stimulation with dendritic cells from: liver versus peripheral lymph nodes (pLN). MSigDB C7: Immunologic Signatures (v5.1) 1.166E-3 3.415E-2
2.813E-1
1.000E0
 3 200
48 GSE22527 ANTI CD3 INVIVO VS UNTREATED MOUSE TREG DN Genes down-regulated in T reg following anti-CD3 in vivo treatment versus control. MSigDB C7: Immunologic Signatures (v5.1) 1.166E-3 3.415E-2
2.813E-1
1.000E0
 3 200
49 GSE9960 GRAM POS VS GRAM NEG AND POS SEPSIS PBMC UP Genes up-regulated in peripheral blood monocytes (PMBC): Gram positive sepsis versus mixed infection sepsis. MSigDB C7: Immunologic Signatures (v5.1) 1.166E-3 3.415E-2
2.813E-1
1.000E0
 3 200
50 GSE37534 GW1929 VS PIOGLITAZONE TREATED CD4 TCELL PPARG1 FOXP3 TRANSDUCED DN Genes down-regulated in CD4 [GeneID=920] T cells over-expressing FOXP3 [GeneID=50943] and PPARg1 isoform of PPARG [GeneID=5468]: GW1929 [PubChem=6518171] versus pioglitazone [PubChem=4829]. MSigDB C7: Immunologic Signatures (v5.1) 1.166E-3 3.415E-2
2.813E-1
1.000E0
 3 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 906 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PP HSC 100 PP HSC top-relative-expression-ranked 100 PCBC 4.018E-6 1.213E-3 8.963E-3 3.640E-3 4 100
2 PP MEP 100 PP MEP top-relative-expression-ranked 100 PCBC 4.018E-6 1.213E-3 8.963E-3 3.640E-3 4 100
3 PP GMP 100 PP GMP top-relative-expression-ranked 100 PCBC 4.018E-6 1.213E-3 8.963E-3 3.640E-3 4 100
4 fetal replicating Top 500 All fetal replicating Top 500 All Brain Map - Barres 1.216E-5 2.466E-3 1.822E-2 1.102E-2 6 496
5 PP RBC 500 K1 PP RBC top-relative-expression-ranked 500 k-means-cluster#1 PCBC 1.361E-5 2.466E-3 1.822E-2 1.233E-2 4 136
6 PP RBC 1000 K1 PP RBC top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 1.847E-5 2.727E-3 2.014E-2 1.673E-2 5 310
7 PP MEG 500 K1 PP MEG top-relative-expression-ranked 500 k-means-cluster#1 PCBC 2.109E-5 2.727E-3 2.014E-2 1.911E-2 4 152
8 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 100 k4 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 k-means-cluster#4 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 2.408E-5 2.727E-3 2.014E-2 2.181E-2 2 7
9 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 100 k2 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 6.289E-5 5.694E-3 4.206E-2
5.698E-2
 2 11
10 GSM605883 500 Myeloid Cells, Mo.6C-II-.Bl, CD115+ B220- CD43- Ly6C- MHCII-, Blood, avg-3 Immgen.org, GSE15907 6.385E-5 5.694E-3 4.206E-2
5.785E-2
 5 402
11 PP epoMEP 500 K1 PP epoMEP top-relative-expression-ranked 500 k-means-cluster#1 PCBC 6.913E-5 5.694E-3 4.206E-2
6.263E-2
 4 206
12 PCBC ratio EB from-OSK-L-l-p53KD vs EB from-ESC cfr-2X-p05 Embryoid Body Cells-reprogram OSK-L-l-p53KD vs Embryoid Body Cells-reprogram NA-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.036E-4 6.656E-3 4.916E-2
9.384E-2
 3 84
13 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 200 k4 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.197E-4 6.656E-3 4.916E-2
1.085E-1
 2 15
14 gudmap developingLowerUrinaryTract e13.5 bladder mesenchyme 200 k1 DevelopingLowerUrinaryTract e13.5 bladder mesenchyme emap-3087 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.368E-4 6.656E-3 4.916E-2
1.239E-1
 2 16
15 PP GMP 500 K3 PP GMP top-relative-expression-ranked 500 k-means-cluster#3 PCBC 1.460E-4 6.656E-3 4.916E-2
1.323E-1
 4 250
16 PP MEP 500 K4 PP MEP top-relative-expression-ranked 500 k-means-cluster#4 PCBC 1.552E-4 6.656E-3 4.916E-2
1.406E-1
 4 254
17 PP MEP 500 PP MEP top-relative-expression-ranked 500 PCBC 1.682E-4 6.656E-3 4.916E-2
1.524E-1
 5 494
18 PP HSC 500 PP HSC top-relative-expression-ranked 500 PCBC 1.682E-4 6.656E-3 4.916E-2
1.524E-1
 5 494
19 PP RBC 500 PP RBC top-relative-expression-ranked 500 PCBC 1.698E-4 6.656E-3 4.916E-2
1.539E-1
 5 495
20 PP GMP 500 PP GMP top-relative-expression-ranked 500 PCBC 1.714E-4 6.656E-3 4.916E-2
1.553E-1
 5 496
21 PP MEG 500 PP MEG top-relative-expression-ranked 500 PCBC 1.730E-4 6.656E-3 4.916E-2
1.568E-1
 5 497
22 PP epoMEP 100 PP epoMEP top-relative-expression-ranked 100 PCBC 1.738E-4 6.656E-3 4.916E-2
1.574E-1
 3 100
23 PP MEG 100 PP MEG top-relative-expression-ranked 100 PCBC 1.738E-4 6.656E-3 4.916E-2
1.574E-1
 3 100
24 PP epoMEP 500 PP epoMEP top-relative-expression-ranked 500 PCBC 1.763E-4 6.656E-3 4.916E-2
1.597E-1
 5 499
25 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 200 k1 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.622E-4 9.502E-3
7.019E-2
2.375E-1
 2 22
26 gudmap dev gonad e12.5 F VasAssocMesStromOvary Sma k3 500 dev gonad e12.5 F VasAssocMesStromOvary Sma k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.762E-4 9.623E-3
7.109E-2
2.502E-1
 3 117
27 Facebase RNAseq e9.5 Mandibular Arch 2500 K2 FacebaseRNAseq e9.5 Mandibular Arch top-relative-expression-ranked 2500 k-means-cluster#2 FaceBase_RNAseq 3.110E-4 1.023E-2
7.553E-2
2.818E-1
 5 564
28 PP MEG 1000 K3 PP MEG top-relative-expression-ranked 1000 k-means-cluster#3 PCBC 3.160E-4 1.023E-2
7.553E-2
2.863E-1
 4 306
29 geo heart 2500 K4 geo heart top-relative-expression-ranked 2500 k-means-cluster#4 PCBC 4.503E-4 1.385E-2
1.023E-1
4.079E-1
 4 336
30 gudmap dev gonad e11.5 F ReproVasc Flk k1 500 dev gonad e11.5 F ReproVasc Flk k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 4.587E-4 1.385E-2
1.023E-1
4.156E-1
 2 29
31 PP HSC 1000 K1 PP HSC top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 4.974E-4 1.454E-2
1.074E-1
4.507E-1
 4 345
32 GSM605886 500 Myeloid Cells, Mo.6C-IIint.Bl, CD115+ B220- CD43- Ly6C- MHCIIint, Blood, avg-5 Immgen.org, GSE15907 8.657E-4 2.388E-2
1.764E-1
7.843E-1
 4 400
33 OPC Top 500 Cluster 1 OPC Top 500 Cluster 1 Brain Map - Barres 8.748E-4 2.388E-2
1.764E-1
7.925E-1
 2 40
34 GSM854306 500 Myeloid Cells, GN.Bl, CD11b+ Ly6-G+, Blood, avg-3 Immgen.org, GSE15907 9.404E-4 2.388E-2
1.764E-1
8.520E-1
 4 409
35 GSM854312 500 Myeloid Cells, GN.UrAc.PC, CD11b+ Ly6-G+, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 9.490E-4 2.388E-2
1.764E-1
8.598E-1
 4 410
36 gudmap dev gonad e12.5 F gudmap devVasOvary Flk k4 1000 dev gonad e12.5 F DevVasOvary Flk k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 9.643E-4 2.388E-2
1.764E-1
8.737E-1
 2 42
37 GSM605878 500 Myeloid Cells, Mo.6C-II+.Bl, CD115+ B220- CD43+ Ly6C- MHCIIhi, Blood, avg-2 Immgen.org, GSE15907 9.751E-4 2.388E-2
1.764E-1
8.834E-1
 4 413
38 GSM854338 500 Myeloid Cells, GN.Arth.SynF, CD11b+ Ly6-G+, Synovial Fluid, avg-3 Immgen.org, GSE15907 1.020E-3 2.431E-2
1.796E-1
9.238E-1
 4 418
39 JC iEC 2500 K5 JC iEC top-relative-expression-ranked 2500 k-means-cluster#5 PCBC 1.226E-3 2.847E-2
2.103E-1
1.000E0
 5 763
40 geo heart 500 K1 geo heart top-relative-expression-ranked 500 k-means-cluster#1 PCBC 1.311E-3 2.969E-2
2.193E-1
1.000E0
 2 49
41 gudmap developingLowerUrinaryTract e13.5 bladder mesenchyme 500 k5 DevelopingLowerUrinaryTract e13.5 bladder mesenchyme emap-3087 k-means-cluster#5 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.365E-3 3.016E-2
2.228E-1
1.000E0
 2 50
42 PP HSC 500 K5 PP HSC top-relative-expression-ranked 500 k-means-cluster#5 PCBC 1.491E-3 3.216E-2
2.376E-1
1.000E0
 3 209
43 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 500 k4 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.532E-3 3.228E-2
2.385E-1
1.000E0
 2 53
44 gudmap developingLowerUrinaryTract e13.5 bladder epithelial cells 500 k4 DevelopingLowerUrinaryTract e13.5 bladder epithelial cells emap-30875 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.590E-3 3.274E-2
2.418E-1
1.000E0
 2 54
45 gudmap dev gonad e11.5 M ReproVasc Flk k2 500 dev gonad e11.5 M ReproVasc Flk k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.832E-3 3.688E-2
2.724E-1
1.000E0
 2 58
46 endothelial SubClass MFSD2-hi Top 500 All endothelial SubClass MFSD2-hi Top 500 All Brain Map - Barres 1.943E-3 3.826E-2
2.826E-1
1.000E0
 4 498
47 gudmap dev gonad e11.5 M GonMes Sma k3 500 dev gonad e11.5 M GonMes Sma k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.090E-3 3.971E-2
2.933E-1
1.000E0
 2 62
48 PP MEP 1000 K3 PP MEP top-relative-expression-ranked 1000 k-means-cluster#3 PCBC 2.104E-3 3.971E-2
2.933E-1
1.000E0
 4 509
49 gudmap developingKidney e15.5 Endothelial cells 100 k4 DevelopingKidney e15.5 Endothelial cells emap-29965 k-means-cluster#4 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 2.192E-3 3.977E-2
2.938E-1
1.000E0
 1 2
50 Facebase ST1 e10.5 Emin MedialNasal 500 3 e10.5 Emin MedialNasal top-relative-expression-ranked 500 3 FaceBase_ST1 2.212E-3 3.977E-2
2.938E-1
1.000E0
 3 240
Show 45 more annotations

15: Computational [Display Chart] 172 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 123 Genes in module 123 MSigDb: C4 - CM: Cancer Modules 2.546E-6 4.378E-4 2.508E-3 4.378E-4 6 240
2 module 197 Genes in module 197 MSigDb: C4 - CM: Cancer Modules 2.045E-4 1.759E-2
1.007E-1
 3.518E-2 4 170

16: MicroRNA [Display Chart] 1062 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-342-3p:PITA hsa-miR-342-3p:PITA TOP PITA 3.781E-5 2.153E-2
1.624E-1
 4.016E-2 4 167
2 CTACTGT,MIR-199A:MSigDB CTACTGT,MIR-199A:MSigDB MSigDB 4.054E-5 2.153E-2
1.624E-1
 4.305E-2 4 170

17: Drug [Display Chart] 8210 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000003973 LY294002 Stitch 2.055E-12 1.687E-8 1.618E-7 1.687E-8 12 750
2 CID000006497 dimethyl sulfate Stitch 1.056E-9 3.357E-6 3.219E-5 8.669E-6 6 107
3 C550547 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide CTD 1.745E-9 3.357E-6 3.219E-5 1.433E-5 5 51
4 CID000176155 SB203580 Stitch 1.936E-9 3.357E-6 3.219E-5 1.589E-5 10 772
5 CID000005562 A25618 Stitch 2.060E-9 3.357E-6 3.219E-5 1.691E-5 10 777
6 CID000004713 PD98059 Stitch 2.811E-9 3.357E-6 3.219E-5 2.308E-5 7 233
7 D003474 Curcumin CTD 2.862E-9 3.357E-6 3.219E-5 2.350E-5 10 804
8 CID000200878 P-38 Stitch 5.298E-9 5.437E-6 5.214E-5 4.349E-5 9 613
9 CID000005637 U0126 Stitch 7.446E-9 6.793E-6 6.514E-5 6.113E-5 8 431
10 CID005326793 Pe v Stitch 1.386E-8 1.138E-5 1.091E-4 1.138E-4 6 164
11 D002211 Capsaicin CTD 1.836E-8 1.370E-5 1.314E-4 1.507E-4 8 484
12 D017382 Reactive Oxygen Species CTD 2.407E-8 1.647E-5 1.579E-4 1.976E-4 7 318
13 410 DN 2-propylpentanoic acid; Down 200; 10000uM; HL60; HG-U133A Broad Institute CMAP 3.234E-8 2.042E-5 1.958E-4 2.655E-4 6 189
14 CID000005591 troglitazone Stitch 3.498E-8 2.052E-5 1.967E-4 2.872E-4 8 526
15 CID000003154 Cosopt Stitch 3.884E-8 2.123E-5 2.036E-4 3.189E-4 7 341
16 CID000004813 AC1L1J0H Stitch 4.138E-8 2.123E-5 2.036E-4 3.398E-4 6 197
17 CID000099040 Sp 1 (pharmaceutical) Stitch 4.800E-8 2.318E-5 2.223E-4 3.941E-4 8 548
18 D019307 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine CTD 5.137E-8 2.343E-5 2.247E-4 4.217E-4 4 36
19 CID000008515 SP600125 Stitch 5.844E-8 2.525E-5 2.422E-4 4.798E-4 7 362
20 CID000006569 methyl ethyl ketone Stitch 8.151E-8 3.346E-5 3.209E-4 6.692E-4 8 587
21 D009536 Niacinamide CTD 9.142E-8 3.499E-5 3.356E-4 7.506E-4 5 111
22 D008687 Metformin CTD 9.377E-8 3.499E-5 3.356E-4 7.699E-4 7 388
23 D001241 Aspirin CTD 2.402E-7 8.361E-5 8.019E-4 1.972E-3 8 676
24 CID000002199 AC1L1D59 Stitch 2.444E-7 8.361E-5 8.019E-4 2.007E-3 6 266
25 D020123 Sirolimus CTD 2.602E-7 8.544E-5 8.194E-4 2.136E-3 7 451
26 D000111 Acetylcysteine CTD 4.048E-7 1.278E-4 1.226E-3 3.324E-3 8 724
27 C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide CTD 4.836E-7 1.470E-4 1.410E-3 3.970E-3 5 155
28 C027576 4-hydroxy-2-nonenal CTD 7.326E-7 2.086E-4 2.001E-3 6.015E-3 8 783
29 CID000554048 methyl-dl-serine hydrochloride Stitch 7.370E-7 2.086E-4 2.001E-3 6.050E-3 4 69
30 C093642 SB 203580 CTD 8.484E-7 2.322E-4 2.227E-3 6.965E-3 6 329
31 423 UP staurosporine; Up 200; 0.1uM; MCF7; HG-U133A Broad Institute CMAP 9.069E-7 2.402E-4 2.303E-3 7.446E-3 5 176
32 CID009829523 PKC412 Stitch 9.775E-7 2.432E-4 2.332E-3 8.025E-3 4 74
33 D008790 Metoprolol CTD 9.775E-7 2.432E-4 2.332E-3 8.025E-3 4 74
34 3397 UP Digoxigenin [1672-46-4]; Up 200; 10.2uM; MCF7; HT HG-U133A Broad Institute CMAP 1.013E-6 2.447E-4 2.347E-3 8.319E-3 5 180
35 D003913 Dextroamphetamine CTD 1.070E-6 2.510E-4 2.407E-3 8.785E-3 5 182
36 D013196 Dihydrotestosterone CTD 1.176E-6 2.682E-4 2.573E-3 9.657E-3 6 348
37 1047 DN 2-propylpentanoic acid; Down 200; 1000uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.393E-6 3.039E-4 2.915E-3 1.143E-2 5 192
38 D000841 Anisomycin CTD 1.407E-6 3.039E-4 2.915E-3 1.155E-2 4 81
39 CID000005056 trans-3,4,5-trihydroxystilbene Stitch 1.926E-6 4.055E-4 3.889E-3 1.581E-2 7 608
40 CID000107707 Zlllal Stitch 2.034E-6 4.174E-4 4.003E-3 1.670E-2 7 613
41 CID000164073 Pkcs Stitch 2.214E-6 4.434E-4 4.252E-3 1.818E-2 5 211
42 CID000130105 CV-1 Stitch 2.319E-6 4.533E-4 4.347E-3 1.904E-2 5 213
43 C012843 cinnamic aldehyde CTD 2.840E-6 5.423E-4 5.200E-3 2.332E-2 5 222
44 CID000449115 B-E4 Stitch 3.107E-6 5.661E-4 5.430E-3 2.551E-2 2 3
45 CID000065768 tryptamide Stitch 3.107E-6 5.661E-4 5.430E-3 2.551E-2 2 3
46 C467566 pomalidomide CTD 3.172E-6 5.661E-4 5.430E-3 2.604E-2 3 28
47 C007517 diphenyleneiodonium CTD 3.272E-6 5.716E-4 5.482E-3 2.686E-2 4 100
48 CID004369394 AR E Stitch 3.377E-6 5.776E-4 5.539E-3 2.772E-2 5 230
49 CID000003591 AC1L1G9T Stitch 4.160E-6 6.970E-4 6.684E-3 3.415E-2 6 433
50 CID000003795 WHI-P154 Stitch 4.344E-6 7.132E-4 6.840E-3 3.566E-2 3 31
Show 45 more annotations

18: Disease [Display Chart] 881 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0243026 Sepsis DisGeNET Curated 1.028E-7 9.053E-5 6.662E-4 9.053E-5 8 443
2 umls:C0007114 Malignant neoplasm of skin DisGeNET BeFree 4.965E-7 2.072E-4 1.525E-3 4.374E-4 6 220
3 umls:C0036690 Septicemia DisGeNET BeFree 7.055E-7 2.072E-4 1.525E-3 6.215E-4 7 383
4 umls:C0023493 Adult T-Cell Lymphoma/Leukemia DisGeNET Curated 2.433E-6 4.378E-4 3.222E-3 2.144E-3 7 461
5 umls:C0850666 Helicobacter pylori infection DisGeNET BeFree 2.485E-6 4.378E-4 3.222E-3 2.189E-3 6 290
6 umls:C0349649 Pulmonary lymphangioleiomyomatosis DisGeNET BeFree 4.386E-6 4.658E-4 3.427E-3 3.864E-3 3 23
7 umls:C1961102 Precursor Cell Lymphoblastic Leukemia Lymphoma DisGeNET Curated 4.629E-6 4.658E-4 3.427E-3 4.079E-3 8 733
8 umls:C0025149 Medulloblastoma DisGeNET Curated 5.061E-6 4.658E-4 3.427E-3 4.459E-3 7 515
9 umls:C0023492 Leukemia, T-Cell DisGeNET Curated 5.610E-6 4.658E-4 3.427E-3 4.942E-3 6 334
10 umls:C0740392 Infarction, Middle Cerebral Artery DisGeNET Curated 5.686E-6 4.658E-4 3.427E-3 5.009E-3 3 25
11 umls:C0220645 childhood soft tissue sarcoma DisGeNET BeFree 5.815E-6 4.658E-4 3.427E-3 5.123E-3 2 3
12 umls:C0238462 Medullary carcinoma of thyroid DisGeNET Curated 7.047E-6 5.174E-4 3.807E-3 6.209E-3 5 196
13 umls:C0023473 Myeloid Leukemia, Chronic DisGeNET Curated 8.125E-6 5.462E-4 4.019E-3 7.158E-3 8 791
14 umls:C0022680 Polycystic Kidney Diseases DisGeNET Curated 8.755E-6 5.462E-4 4.019E-3 7.713E-3 4 94
15 umls:C0023449 Acute lymphocytic leukemia DisGeNET Curated 9.761E-6 5.462E-4 4.019E-3 8.599E-3 8 811
16 umls:C0038220 Status Epilepticus DisGeNET Curated 9.920E-6 5.462E-4 4.019E-3 8.739E-3 4 97
17 umls:C0016667 Fragile X Syndrome DisGeNET Curated 1.518E-5 7.684E-4 5.655E-3 1.338E-2 4 108
18 umls:C0020456 Hyperglycemia DisGeNET Curated 1.570E-5 7.684E-4 5.655E-3 1.383E-2 6 400
19 umls:C0079773 Lymphoma, T-Cell, Cutaneous DisGeNET Curated 1.842E-5 8.409E-4 6.188E-3 1.623E-2 5 239
20 umls:C0007847 Malignant tumor of cervix DisGeNET BeFree 1.909E-5 8.409E-4 6.188E-3 1.682E-2 8 889
21 umls:C0007115 Malignant neoplasm of thyroid DisGeNET BeFree 3.169E-5 1.330E-3 9.784E-3 2.792E-2 6 453
22 umls:C0400966 Non-alcoholic Fatty Liver Disease DisGeNET Curated 3.550E-5 1.404E-3 1.033E-2 3.128E-2 5 274
23 umls:C0751674 Lymphangioleiomyomatosis DisGeNET Curated 3.927E-5 1.404E-3 1.033E-2 3.460E-2 3 47
24 umls:C1512409 Hepatocarcinogenesis DisGeNET BeFree 3.943E-5 1.404E-3 1.033E-2 3.474E-2 6 471
25 umls:C0085413 Polycystic Kidney, Autosomal Dominant DisGeNET Curated 3.984E-5 1.404E-3 1.033E-2 3.510E-2 4 138
26 umls:C1261473 Sarcoma DisGeNET Curated 5.170E-5 1.752E-3 1.289E-2 4.554E-2 7 737
27 umls:C0007103 Malignant neoplasm of endometrium DisGeNET BeFree 5.884E-5 1.851E-3 1.362E-2
5.184E-2
 6 506
28 umls:C1883486 Uterine Corpus Cancer DisGeNET BeFree 5.884E-5 1.851E-3 1.362E-2
5.184E-2
 6 506
29 umls:C0024121 Lung Neoplasms DisGeNET Curated 6.999E-5 2.126E-3 1.565E-2
6.166E-2
 7 773
30 umls:C0019829 Hodgkin Disease DisGeNET Curated 8.347E-5 2.451E-3 1.804E-2
7.353E-2
 5 328
31 umls:C0278828 Stage IV Bladder Cancer AJCC v6 DisGeNET BeFree 8.670E-5 2.464E-3 1.813E-2
7.638E-2
 2 10
32 umls:C0034067 Pulmonary Emphysema DisGeNET Curated 9.821E-5 2.704E-3 1.990E-2
8.653E-2
 4 174
33 umls:C0006840 Candidiasis DisGeNET Curated 1.298E-4 3.465E-3 2.550E-2
1.143E-1
 3 70
34 umls:C0917798 Cerebral Ischemia DisGeNET BeFree 1.352E-4 3.502E-3 2.577E-2
1.191E-1
 4 189
35 umls:C0032285 Pneumonia DisGeNET Curated 1.586E-4 3.992E-3 2.937E-2
1.397E-1
 5 376
36 umls:C0005411 Biliary Atresia DisGeNET Curated 1.657E-4 4.056E-3 2.985E-2
1.460E-1
 3 76
37 umls:C0231341 Premature aging syndrome DisGeNET Curated 1.790E-4 4.263E-3 3.137E-2
1.577E-1
 3 78
38 umls:C0003507 Aortic Valve Stenosis DisGeNET BeFree 1.930E-4 4.405E-3 3.241E-2
1.700E-1
 3 80
39 umls:C0033860 Psoriasis DisGeNET Curated 1.950E-4 4.405E-3 3.241E-2
1.718E-1
 6 629
40 umls:C0549473 Thyroid carcinoma DisGeNET Curated 2.053E-4 4.522E-3 3.328E-2
1.809E-1
 6 635
41 umls:C0041696 Unipolar Depression DisGeNET BeFree 2.242E-4 4.817E-3 3.545E-2
1.975E-1
 5 405
42 umls:C0598766 Leukemogenesis DisGeNET BeFree 2.532E-4 5.138E-3 3.781E-2
2.231E-1
 6 660
43 umls:C1519689 Tumor Promotion DisGeNET BeFree 2.559E-4 5.138E-3 3.781E-2
2.254E-1
 3 88
44 umls:C0039984 Thoracic Outlet Syndrome DisGeNET BeFree 2.604E-4 5.138E-3 3.781E-2
2.295E-1
 2 17
45 umls:C0023487 Acute Promyelocytic Leukemia DisGeNET Curated 2.624E-4 5.138E-3 3.781E-2
2.312E-1
 5 419
46 umls:C0878544 Cardiomyopathies DisGeNET Curated 2.773E-4 5.310E-3 3.908E-2
2.443E-1
 5 424
47 umls:C0040128 Thyroid Diseases DisGeNET Curated 3.012E-4 5.645E-3 4.154E-2
2.653E-1
 3 93
48 umls:C1269683 Major Depressive Disorder DisGeNET Curated 3.154E-4 5.671E-3 4.173E-2
2.779E-1
 5 436
49 umls:C0027765 nervous system disorder DisGeNET Curated 3.154E-4 5.671E-3 4.173E-2
2.779E-1
 5 436
50 umls:C0238463 Papillary thyroid carcinoma DisGeNET Curated 3.502E-4 6.170E-3 4.540E-2
3.085E-1
 5 446
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